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首页> 外文期刊>Journal of clinical neuroscience: official journal of the Neurosurgical Society of Australasia >Risk factors for idiopathic dystonia in Queensland, Australia
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Risk factors for idiopathic dystonia in Queensland, Australia

机译：澳大利亚昆士兰州特发性肌张力障碍的危险因素

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摘要

It is currently hypothesised that a combination of genetic and environmental factors underlies the development of idiopathic isolated dystonia (IID). In this study, we examined several possible environmental or other non-genetic factors that may influence the risk for IID in Queensland, Australia. We surveyed several environmental exposures, lifestyle factors, medical and family histories to investigate potential risk factors for IID. Associations between putative risk factors and IID were assessed using a total of 184 dystonia patients and 1048 neurologically-normal control subjects sampled from Queensland between 2005 and 2012. Our analyses revealed that anxiety disorders, depression, tremor, cigarette smoking and head injuries with a loss of consciousness were associated with increased risk for IID (p < 0.05), all of which remained statistically significant following an adjustment for multiple hypothesis testing except for depression. We also observed that the risk for dystonia increased with higher cigarette smoking pack-year quartiles in our analyses. Our results suggest possible environmental factors that influence the development of IID and complement the findings of similar dystonia risk factor studies. Further investigation defining the environmental and other non-genetic risk factors for IID may provide insight into the development of the disorder in genetically-susceptible individuals. (C) 2014 Elsevier Ltd. All rights reserved.
机译：目前假设遗传因素和环境因素的组合是特发性孤立性肌张力障碍（IID）发生的基础。在这项研究中，我们研究了可能影响澳大利亚昆士兰州IID风险的几种可能的环境或其他非遗传因素。我们调查了几种环境暴露，生活方式因素，医疗和家庭史，以调查IID的潜在危险因素。 2005年至2012年间，从昆士兰州抽取了184名肌张力障碍患者和1048名神经学正常对照者，评估了推定的危险因素与IID之间的关联。我们的分析显示，焦虑障碍，抑郁，震颤，吸烟和头部受伤伴有损失意识障碍与IID风险增加相关（p <0.05），对所有假设进行调整后，除抑郁症外，所有其他因素在统计学上仍具有统计学意义。我们还观察到，在我们的分析中，较高的吸烟包装年数四分位数会增加肌张力障碍的风险。我们的结果表明，可能的环境因素会影响IID的发展，并补充类似的肌张力障碍危险因素研究的结果。定义IID的环境和其他非遗传风险因素的进一步研究可能会为遗传易感人群中疾病的发展提供见识。 （C）2014 Elsevier Ltd.保留所有权利。

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