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首页> 外文期刊>Journal of clinical neuroscience: official journal of the Neurosurgical Society of Australasia >Prognosis by tumor location in adults with intracranial ependymomas
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Prognosis by tumor location in adults with intracranial ependymomas

机译：成人颅内室间隔膜瘤的肿瘤位置预后

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Intracranial ependymomas are rare tumors in adults. Thus, factors affecting prognosis are poorly understood. We performed a study to investigate whether tumor location is an important prognostic factor in adults who undergo surgery for intracranial ependymomas. PubMed was searched to identify studies that reported clinical outcomes in adult patients with intracranial ependymoma. Data were extracted for patient and tumor characteristics, extent of resection, progression-free survival (PFS), and overall survival (OS). Tumors were categorized as supratentorial or infratentorial and extraventricular or intraventricular. Presenting clinical features and tumor characteristics were tabulated. Kaplan-Meier and multivariate Cox regression survival analyses were performed to determine PFS and OS by tumor location. Extent of resection was also analyzed by tumor location. A total of 183 patients were included in the meta-analysis. Patients presented at a mean of 8.2 months with a myriad of clinical features. The mean tumor size was 3.38 cm, and 19.3% of tumors were cystic. Supratentorial tumors were most commonly located in the frontal and parietal lobes, and infratentorial tumors in the fourth ventricle. Supratentorial tumors demonstrated significantly poorer PFS (p < 0.001) and OS (p = 0.003) than infratentorial tumors, despite a higher rate of gross total resection (GTR) for the supratentorial tumors (72.6% versus 42.1%). Extraventricular ependymomas displayed significantly poorer PFS than intraventricular ependymomas (p = 0.009). In summary, supratentorial ependymomas have significantly poorer PFS and OS than their infratentorial counterparts, despite being more conducive to GTR, suggesting increased clinical aggressiveness. Extraventricular location is also associated with significantly poorer PFS than intraventricular location. (C) 2014 Elsevier Ltd. All rights reserved.
机译：颅内室间隔膜瘤是成年人中罕见的肿瘤。因此，影响预后的因素知之甚少。我们进行了一项研究，以调查在接受颅内室间隔膜瘤手术的成年人中，肿瘤的位置是否是重要的预后因素。搜索PubMed以鉴定报告了颅内室间隔膜瘤成年患者临床结局的研究。提取患者和肿瘤特征，切除范围，无进展生存期（PFS）和总体生存期（OS）的数据。肿瘤分为幕上或脑下和脑室外或脑室内。列出临床特征和肿瘤特征。进行Kaplan-Meier和多元Cox回归生存分析，以通过肿瘤位置确定PFS和OS。还通过肿瘤位置分析了切除的程度。荟萃分析共纳入183例患者。患者平均呈现8.2个月的临床特征。平均肿瘤大小为3.38 cm，19.3％的肿瘤为囊性。幕上肿瘤最常见于额叶和顶叶，而幕下肿瘤位于第四脑室。尽管幕上肿瘤的总全切除率（GTR）较高（72.6％比42.1％），但幕上肿瘤的PFS（p <0.001）和OS（p = 0.003）显着低于幕下肿瘤。脑室内室间隔膜瘤的PFS明显低于脑室内室间隔膜瘤（p = 0.009）。综上所述，尽管幕上室间隔膜瘤更有利于GTR，但其PFS和OS较其下腹膜相比差得多，提示其临床攻击性增强。与脑室内定位相比，脑室内定位还与PFS明显差有关。 （C）2014 Elsevier Ltd.保留所有权利。

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