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首页> 外文期刊>Journal of Clinical Oncology >Validation of patient's self-reported social functioning as an independent prognostic factor for survival in metastatic colorectal cancer patients: results of an international study by the Chronotherapy Group of the European Organisation for Research
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Validation of patient's self-reported social functioning as an independent prognostic factor for survival in metastatic colorectal cancer patients: results of an international study by the Chronotherapy Group of the European Organisation for Research

机译：验证患者自我报告的社会功能作为转移性结直肠癌患者生存的独立预后因素：欧洲研究组织计时疗法小组的一项国际研究结果

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PURPOSE: A recent study identified a prognostic model for survival in metastatic colorectal cancer patients which included WBC count, alkaline phosphatase (AP), number of metastatic sites, and patients' self-reported social functioning. The aim of this research is to validate this model on data from an independent sample. PATIENTS AND METHODS: This validation study is based on a prospective randomized controlled trial in patients with metastatic colorectal cancer conducted by the European Organisation for Research and Treatment of Cancer (EORTC) Chronotherapy Group. Overall, 564 patients in 10 countries were enrolled. For the purpose of this independent validation, patients with health-related quality of life (HRQOL) baseline data were analyzed. HRQOL was assessed using the EORTC Quality of Life Questionnaire C30 (QLQ-C30). The Cox proportional hazards regression model was used for both univariate and multivariate analyses of survival. RESULTS: The previous model with an additional adjustment, by stratification for sex, was replicated and its parameters were confirmed to independently predict survival: WBC count with an hazard ratio (HR) of 1.31 (95% CI, 1.021 to 1.698; P = .034); AP with an HR of 1.53 (95% CI, 1.188 to 1.979; P = .001); number of sites involved with an HR of 1.90 (95% CI, 1.531 to 2.364; P < .0001); and patients' self-reported social functioning with an HR of 0.94 (95% CI, 0.905 to 0.976; P = .001). The latter translates into a 6% increase in the likelihood of an earlier death for every 10-point decrease in the social functioning scale of the EORTC QLQ-C30. CONCLUSION: This study provides confirmatory evidence of the independent prognostic value of patients' self-reported social functioning in patients with advanced colorectal cancer.
机译：目的：最近的一项研究确定了转移性结直肠癌患者的生存的预后模型，包括WBC计数，碱性磷酸酶（AP），转移部位的数目以及患者自我报告的社会功能。这项研究的目的是对来自独立样本的数据验证该模型。患者和方法：这项验证研究基于欧洲癌症研究与治疗组织（EORTC）慢性疗法组对转移性结直肠癌患者进行的前瞻性随机对照试验。总体而言，共有10个国家的564名患者入选。为了进行独立验证，对具有健康相关生活质量（HRQOL）基线数据的患者进行了分析。使用EORTC生活质量问卷C30（QLQ-C30）对HRQOL进行了评估。 Cox比例风险回归模型用于生存的单变量和多变量分析。结果：复制了先前的模型，该模型通过按性别分层进行了额外的调整，并确定了其参数以独立预测生存：WBC计数，危险比（HR）为1.31（95％CI，1.021至1.698; P =。 034）; HR为1.53（95％CI，1.188至1.979; P = .001）; HR涉及1.90的站点数（95％CI，1.531至2.364; P <.0001）;和患者自我报告的社交功能，HR为0.94（95％CI，0.905至0.976; P = .001）。后者意味着EORTC QLQ-C30的社交功能范围每降低10点，则较早死亡的可能性增加6％。结论：本研究为晚期大肠癌患者自我报告的社会功能的独立预后价值提供了验证性证据。

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