The Bromodomain Inhibitor JQ1 and the Histone Deacetylase Inhibitor Panobinostat Synergistically Reduce N-Myc Expression and Induce Anticancer Effects

Shahbazi Jeyran; Liu Pei Y.; Atmadibrata Bernard; Bradner James E.; Marshall Glenn M.; Lock Richard B.; Liu Tao

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The Bromodomain Inhibitor JQ1 and the Histone Deacetylase Inhibitor Panobinostat Synergistically Reduce N-Myc Expression and Induce Anticancer Effects

机译：Bromodomain抑制剂JQ1和组蛋白脱乙酰基酶抑制剂Panobinostat协同降低N-Myc表达并诱导抗癌作用

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Purpose: Patients with neuroblastoma associated with MYCN oncogene amplification experience a very poor prognosis. BET bromodomain inhibitors are among the most promising novel anticancer agents as they block BRD3 and BRD4 from activating oncogene transcription. However, treatment with BET bromodomain inhibitors alone does not result in cancer remission in many murine models.

机译：目的：伴有MYCN癌基因扩增的神经母细胞瘤患者预后很差。 BET溴结构域抑制剂是最有前途的新型抗癌药，因为它们阻止BRD3和BRD4激活癌基因转录。但是，在许多小鼠模型中，仅使用BET溴结构域抑制剂治疗不会导致癌症缓解。

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《Clinical cancer research: an official journal of the American Association for Cancer Research》 |2016年第10期|共11页
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Shahbazi Jeyran; Liu Pei Y.; Atmadibrata Bernard; Bradner James E.; Marshall Glenn M.; Lock Richard B.; Liu Tao;
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正文语种 eng
中图分类肿瘤学;
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1. The Bromodomain Inhibitor JQ1 and the Histone Deacetylase Inhibitor Panobinostat Synergistically Reduce N-Myc Expression and Induce Anticancer Effects [J] . Shahbazi Jeyran, Liu Pei Y., Atmadibrata Bernard, Clinical cancer research: an official journal of the American Association for Cancer Research . 2016,第10期

机译：Bromodomain抑制剂JQ1和组蛋白脱乙酰基酶抑制剂Panobinostat协同降低N-Myc表达并诱导抗癌作用
2. The histone deacetylase inhibitor panobinostat exerts anticancer effects on esophageal squamous cell carcinoma cells by inducing cell cycle arrest [J] . Cheng Yin‐Wei, Liao Lian‐Di, Yang Qian, Cell biochemistry and function . 2018,第8期

机译：通过诱导细胞循环骤停，组蛋白脱乙酰化酶抑制剂Panobinostat对食管鳞状细胞癌细胞产生抗癌影响
3. Histone deacetylase inhibitor panobinostat induces clinical responses with associated alterations in gene expression profiles in cutaneous T-cell lymphoma. [J] . Ellis L, Pan Y, Smyth GK, Clinical cancer research: an official journal of the American Association for Cancer Research . 2008,第14期

机译：组蛋白脱乙酰基酶抑制剂panobinostat诱导皮肤T细胞淋巴瘤的临床反应及相关基因表达谱的改变。
4. The Tricyclic Antidepressant Amitriptyline Inhibits D-Cyclin Transactivation and Induces Myeloma Cell Apoptosis by Inhibiting Histone Deacetylases: In Vitro and In Silico Evidence [C] . Xinliang Mao, Depei Wu, Suzanne Trudel, International conference of molecular simulations and applied informatics technologies . 2012

机译：三环抗抑郁药阿米替林通过抑制组蛋白脱乙酰基酶抑制D-cyclin反式激活并诱导骨髓瘤细胞凋亡：体外和计算机证据。
5. Synergistic effects of histone deacetylase and DNA methyltransferase inhibitors on T24 cancer cells [D] . Escobar, Sonia. 2006

机译：组蛋白脱乙酰基酶和DNA甲基转移酶抑制剂对T24癌细胞的协同作用
6. Novel histone deacetylase inhibitor MPT0G009 induces cell apoptosis and synergistic anticancer activity with tumor necrosis factor-related apoptosis-inducing ligand against human hepatocellular carcinoma [O] . Mei-Chuan Chen, Hui-Hsuan Huang, Chin-Yu Lai, 2016

机译：新型组蛋白脱乙酰基酶抑制剂MPT0G009与肿瘤坏死因子相关的凋亡诱导配体抗人肝细胞癌诱导细胞凋亡和协同抗癌活性
7. The bromodomain inhibitor jq1 and the histone deacetylase inhibitor panobinostat synergistically reduce n-myc expression and induce anticancer effects [O] . Shahbazi J, Liu PY, Atmadibrata B, 2016

机译：溴结构域抑制剂jq1和组蛋白脱乙酰基酶抑制剂panobinostat协同降低n-myc表达并诱导抗癌作用

The Bromodomain Inhibitor JQ1 and the Histone Deacetylase Inhibitor Panobinostat Synergistically Reduce N-Myc Expression and Induce Anticancer Effects

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