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首页> 外文期刊>Journal of clinical periodontology >Lack of short-term adjunctive effect of systemic neridronate in non-surgical periodontal therapy of advanced generalized chronic periodontitis: an open label-randomized clinical trial.
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Lack of short-term adjunctive effect of systemic neridronate in non-surgical periodontal therapy of advanced generalized chronic periodontitis: an open label-randomized clinical trial.

机译：晚期神经性全身性牙周炎的非手术性牙周治疗中缺乏系统性神经苷酸的短期辅助作用：一项开放标签随机临床试验。

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AIM: To determine if the adjunctive use of intra-muscular neridronate (NE) during non-surgical periodontal treatment (PT) provides, in patients with generalized chronic periodontitis (GCP), adjunctive benefits as compared with PT alone 3 months after the completion of a 3-month NE therapy. MATERIAL AND METHODS: Sixty GCP healthy patients were randomly assigned to control (CG) or test group (TG). CG patients received PT only. Thirty subjects in TG also received adjunctive NE (12.5 mg in an i.m. injection/week for 3 months). Clinical parameters were evaluated at baseline, at the end of NE treatment (3 months after PT) and 3 months after the completion of NE treatment (6 months after the beginning of PT). RESULTS: Groups were balanced at baseline and all clinical parameters showed improvement between baseline and follow-ups. At 6 months improvements from baseline at sites with deep pocket depth (>or=7 mm) were 3.2 mm [95% confidence interval (CI): 2.7-3.9] in CG and 3.0 mm (95% CI: 2.3-3.8) in TG with a non-significant difference of 0.2 mm (95% CI: -1.0-0.5; ANCOVA; p=0.549) between groups. Secondary outcomes did not show significant differences between groups. No major adverse events were reported. CONCLUSIONS: The adjunctive use of NE during PT did not result in additional short-term improvements in periodontal conditions of GCP patients when compared with PT.
机译：目的：确定在非手术性牙周治疗（PT）期间对肌无力神经内酯（NE）的辅助使用是否对广义慢性牙周炎（GCP）的患者在完成3个月后相比单独给予PT提供了辅助益处3个月的NE疗法。材料与方法：将60例GCP健康患者随机分为对照组（CG）或测试组（TG）。 CG患者仅接受PT。 TG的30名受试者也接受了辅助性NE（在每周3个月的每周一次针剂中注射12.5 mg）。在基线，NE治疗结束时（PT后3个月）和NE治疗完成后3个月（PT开始后6个月）评估临床参数。结果：各组在基线时保持平衡，所有临床参数均显示基线和随访之间有所改善。在6个月时，深袋深度（> = 7mm）的基线相对于基线的改善为CG的3.2 mm [95％置信区间（CI）：2.7-3.9]和3.0毫米（95％CI：2.3-3.8）。两组之间的TG差异不显着，为0.2 mm（95％CI：-1.0-0.5; ANCOVA; p = 0.549）。次要结局在两组之间没有显着差异。没有重大不良事件的报道。结论：与PT相比，PT期间NE的辅助使用并没有导致GCP患者牙周状况的其他短期改善。

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