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首页> 外文期刊>Journal of clinical periodontology >Clinical and microbiological benefits of metronidazole alone or with amoxicillin as adjuncts in the treatment of chronic periodontitis: a randomized placebo-controlled clinical trial.
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Clinical and microbiological benefits of metronidazole alone or with amoxicillin as adjuncts in the treatment of chronic periodontitis: a randomized placebo-controlled clinical trial.

机译：甲硝唑单独或与阿莫西林作为辅助剂治疗慢性牙周炎的临床和微生物学益处：一项随机安慰剂对照的临床试验。

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AIM: To evaluate the effects of the adjunctive use of metronidazole (MTZ) or MTZ+amoxicillin (AMX) in the treatment of generalized chronic periodontitis (ChP). MATERIALS AND METHODS: Fifty-one subjects (n=17/group) were randomly assigned to receive scaling and root planing (SRP) only or combined with MTZ (400 mg t.i.d.) or MTZ+AMX (500 mg t.i.d.) for 14 days. Clinical and microbiological examinations were performed at baseline and 3 months post-SRP. Nine plaque samples/subject were analysed by checkerboard DNA-DNA hybridization for 40 bacterial species. RESULTS: Subjects receiving MTZ+AMX exhibited a greater mean gain of clinical attachment, reduction in probing depth (PD) in intermediate and deep sites and a lower percentage of sites with PD5 mm at 3 months, in comparison with those treated with SRP only (p<0.05). The major benefit from the adjunctive use of MTZ was a greater reduction in PD in deep sites. SRP+MTZ+AMX was the only treatment that significantly reduced the levels and proportions of all red complex pathogens and elicited a significantly greater beneficial change in the microbial profile in comparison with SRP only. CONCLUSION: The adjunctive use of MTZ+AMX offers short-term clinical and microbiological benefits, over SRP alone, in the treatment of non-smokers subjects with generalized ChP. The added benefits of MTZ were less evident.
机译：目的：评估甲硝唑（MTZ）或MTZ +阿莫西林（AMX）的辅助使用对广义慢性牙周炎（ChP）的治疗作用。材料和方法：51名受试者（n = 17 /组）被随机分配为仅接受洗牙和根部刨光（SRP）或与MTZ（400 mg t.i.d.）或MTZ + AMX（500 mg t.i.d.）联合治疗14天。在基线和SRP后3个月进行临床和微生物学检查。通过棋盘DNA-DNA杂交分析了40种细菌的九种噬菌斑样品/受试者。结果：与仅接受SRP治疗的受试者相比，接受MTZ + AMX的受试者在3个月时表现出更高的平均临床依从性，中，深位探查深度（PD）减少，PD5 mm的部位百分比更低（ p ＜0.05）。辅助使用MTZ的主要好处是深处PD的降低更大。与仅使用SRP相比，SRP + MTZ + AMX是唯一可以显着降低所有红色复杂病原体的水平和比例并在微生物方面产生明显更大有益变化的治疗方法。结论：与单独使用SRP相比，MTZ + AMX的辅助使用可提供短期的临床和微生物学益处，可治疗非吸烟者的ChP。 MTZ的附加好处不太明显。

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