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首页> 外文期刊>Journal of Clinical Pharmacy and Therapeutics >Prospective evaluation of ten methods for estimating creatinine clearance in children with varying degrees of renal dysfunction.
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Prospective evaluation of ten methods for estimating creatinine clearance in children with varying degrees of renal dysfunction.

机译：对不同程度肾功能不全患儿肌酐清除率评估的十种方法的前瞻性评估。

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The objective of this study was to evaluate ten methods for calculating creatinine clearance (Clcr) in children with renal dysfunction. The design was a prospective, comparative study using 24-h urinary Clcr as the criterion standard. Twenty-two children (age 7-16 years old) were studied. Urinary Clcr ranged from 0 to 161 ml/min/1.73 m2. Calculated Clcr and 24-h urinary Clcr were evaluated statistically. Linear regression analysis, nominal frequency, and mean relative error were used to rank the methods. Children were stratified based on gender and renal function. None of the methods correlated well when Clcr > 100 ml/min/1.73 m2. Predictive performance deteriorated as Clcr decreased. Simple methods using height and serum creatinine were best. Clcr (ml/min/1.73 m2) = (0.52 x height (cm)/serum creatinine)--3.6 was the best equation for estimating Clcr in our patient population consisting of children over 7 years of age with stable serum creatinine.
机译：这项研究的目的是评估十种计算肾功能不全儿童肌酐清除率（Clcr）的方法。该设计是一项前瞻性比较研究，以24小时尿Clcr为标准。研究了22名儿童（年龄7-16岁）。尿Clcr为0至161 ml / min / 1.73 m2。对计算的Clcr和24小时尿Clcr进行统计学评估。使用线性回归分析，标称频率和平均相对误差对方法进行排名。根据性别和肾功能对儿童进行分层。当Clcr> 100 ml / min / 1.73 m2时，这些方法都没有很好的相关性。预测性能随Clcr降低而恶化。使用身高和血清肌酐的简单方法是最好的。 Clcr（ml / min / 1.73 m2）=（0.52 x身高（cm）/血清肌酐）-3.6是估算由7岁以上有稳定血清肌酐的儿童组成的患者人群中Clcr的最佳方程式。

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