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首页> 外文期刊>Journal of Clinical Pharmacy and Therapeutics >What do the suffixes - XR, ER, Chrono, Chronosphere - really mean as It pertains to modified-release antiepileptic drugs?
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What do the suffixes - XR, ER, Chrono, Chronosphere - really mean as It pertains to modified-release antiepileptic drugs?

机译：XR，ER，Chrono，Chronosphere的后缀是什么意思，因为它与缓释抗癫痫药有关？

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Background: Epilepsy is a disease requiring chronic therapy with antiepileptic drugs (AEDs). Many conventional AEDs currently available have either too rapid an absorption or elimination, requiring the patient to take multiple doses per day, which may adversely impact adherence or cause peak-related side-effects. Consequently, some AEDs with immediate-release characteristics have been modified to prolong absorption and/or reduce peak serum concentration, enabling dosage regimen simplification. Modi-fied-release (MR) AED formulations have been labelled with various suffixes or names ('XR, ER, -Chrono, -Chronosphere'), but such labelling may not adequately distinguish those MR AEDs with the most prolonged absorption or unique formulation characteristics. Such suffixes lack precise definition.Objective: We identified the formulation characteristics of currently available MR AEDs, attempting to distinguish them by suffix designation.Design/methods: Nine MR AED formulations, representing six different AEDs, were characterized, utilizing information from FDA-approved inserts (2001 +) and published literature.Results: The formulation characteristics of commercially available MR AEDs are quite variable and do not appear to correlate with their brand name suffix.Conclusions: When all MR AEDs are compared, suffix designations do not provide distinguishable information about formulation characteristics. Clarification of MR AED suffix terminology may be warranted.
机译：背景：癫痫病是一种需要使用抗癫痫药物（AED）进行长期治疗的疾病。当前可用的许多常规AED吸收或消除速度太快，要求患者每天服用多剂，这可能会对依从性产生不利影响或引起与峰相关的副作用。因此，一些具有速释特性的AED已被改良以延长吸收和/或降低血清峰值浓度，从而简化了剂量方案。改良释放（MR）AED制剂已标有各种后缀或名称（'XR，ER，-Chrono，-Chronosphere'），但此类标签可能无法充分区分吸收时间最长或独特的MR AED。特征。这些后缀缺乏精确的定义。目的：我们确定了当前可用的MR AED的配方特征，试图通过后缀名称来区分它们。设计/方法：利用FDA批准的信息，对代表六个不同AED的九种MR AED配方进行了表征。插入（2001 +）和已发表的文献。结果：市售MR AED的配方特性变化很大，似乎与它们的商标后缀无关。结论：当比较所有MR AED时，后缀名称未提供可区分的信息关于配方特性。可能需要澄清MR AED后缀的术语。

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