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首页> 外文期刊>Journal of Clinical Pharmacy and Therapeutics >A comprehensive 4-year survey of adverse drug reactions using a network-based hospital system
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A comprehensive 4-year survey of adverse drug reactions using a network-based hospital system

机译：使用基于网络的医院系统对药物不良反应进行为期4年的全面调查

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What is known and Objective: Spontaneous Adverse Drug Reaction Reporting Systems (ADRRS) provide early warnings or 'signals' for adverse drug reactions (ADRs). Our aim was to survey reports of ADRs made through our teaching-hospital-based pharmacovigilance system to identify the drugs most commonly associated with allergies and the types of immunological reactions reported. Methods: Adverse drug reactions records were retrieved from our network-based electronic notification system. Results and Discussion: Four hundred and seventy four reports of adverse drug effects were studied. 37·3% of the reactions were immune-mediated drug hypersensitivity reactions. True drug hypersensitivity reactions involving IgE-mediated drug allergies accounted for 15% of all reactions. Of the drug hypersensitivity reactions, more than half (67%) were morbilliform skin eruptions, whereas cases of urticaria accounted for 20%. Antibiotics (33% of cases) were the most commonly reported drug allergies, followed by non-steroidal anti-inflammatory drugs (13%) and anti-epileptic agents (10%). What is new and Conclusions: A hospital-based ADR reporting system can generate useful data. In our study, antibiotics accounted for the majority of drug allergies, particularly anaphylactic reactions. More cases of drug allergies were owing to cephalosporin allergies than penicillins. Anti-epileptic agents caused most of the severe drug hypersensitivity syndromes.
机译：已知和目标：自发药物不良反应报告系统（ADRRS）为药物不良反应（ADR）提供预警或“信号”。我们的目的是调查通过我们基于教学医院的药物警戒系统制作的ADR报告，以确定最常与过敏相关的药物和所报告的免疫反应类型。方法：从我们基于网络的电子通知系统中检索药物不良反应记录。结果与讨论：研究了474例药物不良反应报告。反应的37·3％是免疫介导的药物超敏反应。涉及IgE介导的药物过敏的真正药物超敏反应占所有反应的15％。在药物超敏反应中，一半以上（67％）是菌状皮肤爆发，而荨麻疹病例占20％。抗生素（占病例的33％）是最常见的药物过敏，其次是非甾体类抗炎药（13％）和抗癫痫药（10％）。新内容和结论：基于医院的ADR报告系统可以生成有用的数据。在我们的研究中，抗生素占药物过敏的大部分，尤其是过敏反应。头孢菌素过敏引起的药物过敏病例多于青霉素类。抗癫痫药引起大多数严重的药物超敏反应综合征。

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