...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Clinical Pharmacy and Therapeutics >Frequency of dosage prescribing medication errors associated with manual prescriptions for very preterm infants
【24h】

Frequency of dosage prescribing medication errors associated with manual prescriptions for very preterm infants

机译：极早产儿处方与人工处方有关的用药错误的剂量频率

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

What is known and objective: The risk of dosage Prescription Medication Error (PME) among manually written prescriptions within 'mixed' prescribing system (computerized physician order entry (CPOE) + manual prescriptions) has not been previously assessed in neonatology. This study aimed to evaluate the rate of dosage PME related to manual prescriptions in the high-risk population of very preterm infants (GA < 33 weeks) in a mixed prescription system. Methods: The study was based on a retrospective review of a random sample of manual daily prescriptions in two neonatal intensive care units (NICU) A and B, located in different French University hospitals (Dijon and La Reunion island). Daily prescription was defined as the set of all drugs manually prescribed on a single day for one patient. Dosage error was defined as a deviation of at least ±10% from the weight-appropriate recommended dose. Results and discussion: The analyses were based on the assessment of 676 manually prescribed drugs from NICU A (58 different drugs from 93 newborns and 240 daily prescriptions) and 354 manually prescribed drugs from NICU B (73 different drugs from 131 newborns and 241 daily prescriptions). The dosage error rate per 100 manually prescribed drugs was similar in both NICU: 3·8% (95% CI: 2·5-5·6%) in NICU A and 3·1% (95% CI: 1·6-5·5%) in NICU B (P = 0·54). Among all the 37 identified dosage errors, the over-dosing was almost as frequent as the under-dosing (17 and 20 errors, respectively). Potentially severe dosage errors occurred in a total of seven drug prescriptions. None of the dosage PME was recorded in the corresponding medical files and information on clinical outcome was not sufficient to identify clinical conditions related to dosage PME. Overall, 46·8% of manually prescribed drugs were off label or unlicensed, with no significant differences between prescriptions with or without dosage error. The risk of a dosage PME increased significantly if the drug was included in the CPOE system but was manually prescribed (OR = 3·3; 95% CI: 1·6-7·0, P < 0·001). What is new and conclusion: The presence of dosage PME in the manual prescriptions written within mixed prescription systems suggests that manual prescriptions should be totally avoided in neonatal units.
机译：已知和客观的：以前尚未在新生儿科中评估过“混合”处方系统（计算机医师处方录入（CPOE）+手动处方）中手动书写的处方之间的处方处方用药错误（PME）的风险。这项研究旨在评估混合处方系统中早产儿高危人群（GA <33周）与手动处方相关的PME剂量比率。方法：本研究基于回顾性回顾，回顾了位于法国不同大学医院（第戎和拉留尼汪岛）的两个新生儿重症监护病房（NICU）A和B中每日手动处方的随机样本。每日处方被定义为一天中一位患者手动处方的所有药物的集合。剂量误差定义为与体重适当的推荐剂量相差至少±10％。结果与讨论：分析基于对NICU A的676种手动处方药（93种新生儿的58种不同药物和240种日常处方）和NICU B的354种人工处方药（131种新生儿和241种日常处方的73种不同药物）的评估基础）。在两种重症监护病房中，每100种手动处方药的剂量错误率相似：在重症监护病房A中为3·8％（95％CI：2·5-5·6％）和3·1％（95％CI：1·6-）在NICU B中为5·5％）（P = 0·54）。在所有37种确定的剂量错误中，过量服用几乎与剂量不足一样频繁（分别为17和20个错误）。总共七种药物处方中可能出现严重的剂量错误。没有在相应的医学档案中记录任何剂量的PME，有关临床结局的信息不足以鉴定与剂量PME相关的临床状况。总体而言，有46·8％的手动处方药是不贴标签或未经许可的，处方之间的有或没有剂量误差均无显着差异。如果将药物包含在CPOE系统中但手动处方，则服用PME的风险显着增加（OR = 3·3; 95％CI：1·6-7·0，P <0·001）。新内容和结论：在混合处方系统中编写的手动处方中存在剂量PME，这表明应完全避免在新生儿单位中使用手动处方。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号