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首页> 外文期刊>Journal of clinical gastroenterology >Lansoprazole versus lansoprazole plus amoxicillin treatment for eradication of Helicobacter pylori in patients with gastric ulcer.
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Lansoprazole versus lansoprazole plus amoxicillin treatment for eradication of Helicobacter pylori in patients with gastric ulcer.

机译：兰索拉唑vs兰索拉唑加阿莫西林治疗在胃溃疡患者中根除幽门螺杆菌的作用。

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Helicobacter pylori is a major cause of gastritis and an important factor in duodenal ulcer relapse. Eradication of H. pylori has usually been achieved by triple therapy, a combination of bismuth salts and two antibiotics. The disadvantage of these regimens is the large number of tablets and the high incidence of side effects. A new H+,K(+)-ATPase inhibitor, lansoprazole (LPZ), has a strong acid inhibitory effect and an anti-H. pylori effect in vitro. These dual effects have an advantage for the eradication of H. pylori by LPZ alone or by a combination of LPZ and antibiotics. In this study, we investigated an anti-H. pylori effect of LPZ alone and LPZ plus low-dose amoxicillin and the relation between the status of H. pylori colonization and the endoscopic healing stage. LPZ monotherapy suppressed H. pylori but did not eradicate it. LPZ plus low-dose amoxicillin dual therapy eradicated H. pylori in 45.5% of patients with gastric ulcer disease. However, this rate is not satisfactory for eradication therapy. The optimal dosage and duration of treatment need to be specified. A high rate of healing to the endoscopic S2 stage was achieved by eradication of H. pylori and the recurrence of gastric ulcer was suppressed in patients in whom H. pylori was eradicated. The eradication of H. pylori may change the natural course of gastric ulcer disease as it does in duodenal ulcer disease.
机译：幽门螺杆菌是胃炎的主要原因，也是十二指肠溃疡复发的重要因素。幽门螺杆菌的根除通常通过三联疗法，铋盐和两种抗生素的结合来实现。这些方案的缺点是大量的片剂和高发生的副作用。新型H +，K（+）-ATPase抑制剂Lansoprazole（LPZ）具有强酸抑制作用和抗H的作用。幽门螺杆菌的体外作用。这些双重作用对于通过单独的LPZ或通过结合LPZ和抗生素消除幽门螺杆菌具有优势。在这项研究中，我们研究了抗H。单独使用LPZ和LPZ加小剂量阿莫西林对幽门螺杆菌的作用以及幽门螺杆菌定植状态与内镜愈合阶段之间的关系。 LPZ单一疗法可抑制幽门螺杆菌，但不能根除。 LPZ加小剂量的阿莫西林双重疗法根除幽门螺杆菌在45.5％的胃溃疡病患者中。但是，该比率对于根除疗法并不令人满意。需要指定最佳剂量和治疗持续时间。根除幽门螺杆菌可实现高治愈率至内镜S2期，根除幽门螺杆菌的患者可抑制胃溃疡的复发。根除幽门螺杆菌可能会改变胃溃疡疾病的自然进程，就像十二指肠溃疡疾病一样。

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