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首页> 外文期刊>Journal of clinical apheresis. >Peripheral blood stem cell recovery following early termination of apheresis due to hypotension in a 4.8-kg infant.
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Peripheral blood stem cell recovery following early termination of apheresis due to hypotension in a 4.8-kg infant.

机译：4.8千克婴儿因低血压而导致的单采早期终止后外周血干细胞恢复。

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We report a case in which peripheral blood stem cells (PBSC) were successfully recovered following early termination of a collection procedure due to hypotension in a 7-month-old patient. The patient was diagnosed at 4 months of age with neuroblastoma stage IV-S with favorable Shimada histology. She had completed two cycles of chemotherapy before the PBSC collection (PSCC). The procedure was performed on the Cobe Spectra in manual mode, and terminated after 35 min due to severe hypotension. Etiologies considered for the hypotensive episode included a transfusion reaction to the unit of red blood cells (RBC) used for priming the Spectra, citrate reaction, and hypovolemia due to blood drawn for laboratory testing and fluid shifts at the beginning of the procedure. Hypovolemia was ultimately determined to be the most likely etiology. A rinseback was performed into a transfer bag, and the cells were sent to the laboratory for analysis of CD34+ cell yield, volume reduction, and cryopreservation. An adequate number of PBSC were recovered to permit successful autologous transplantation. The ability to recover PBSC from the Spectra white blood cell collection set allowed the patient to avoid undergoing another PSCC. In procedures involving small children, the blood volume drawn for preprocedure testing should be limited to less than 10% of the patient's total blood volume, and the RBC prime should at a minimum replace the entire extracorporeal volume. If the procedure must be terminated early, sufficient PBSC may be recoverable from the blood in the apheresis instrument.
机译：我们报告了一个案例，其中由于7个月大患者的低血压，在早期终止收集程序后成功恢复了外周血干细胞（PBSC）。该患者在4个月大时被诊断为IV-S期神经母细胞瘤，岛田组织学良好。在PBSC收集（PSCC）之前，她已经完成了两个化疗周期。该程序在Cobe Spectra上以手动模式执行，由于严重的低血压，在35分钟后终止。考虑降压发作的病因包括对用于引发光谱的红细胞（RBC）的输血反应，柠檬酸盐反应以及由于在实验室开始抽血用于实验室测试以及在手术开始时出现体液移位而引起的血容量不足。低血容量最终被确定为最可能的病因。将漂洗液倒入转移袋中，并将细胞送至实验室以分析CD34 +细胞的产量，体积减少和冷冻保存。回收了足够数量的PBSC，以成功进行自体移植。从Spectra白细胞收集装置中回收PBSC的能力使患者避免再次接受PSCC。在涉及小孩的手术中，用于术前测试的血液量应限制在患者总血量的10％以下，并且RBC素应至少替代整个体外血量。如果必须尽早终止手术，则单采血液分离术器械血液中可回收足够的PBSC。

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