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首页> 外文期刊>Journal of clinical apheresis. >Bone marrow processing with the AMICUS separator system.
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Bone marrow processing with the AMICUS separator system.

机译：使用AMICUS分离器系统进行骨髓处理。

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摘要

ABO incompatible bone marrow transplantation (BMT) requires processing of the donated bone marrow (BM), either erythrocyte depletion, or also a volume reduction. The AMICUS system was introduced in the field of peripheral blood mononuclear cell collection, showing a good performance regarding efficiency and safety. To evaluate the performance of the MNC collection program of the Amicus device for BM, we analysed our data obtained from the Amicus and the Fenwal CS3000omnix plus device. METHODS: From 2005 to 2008, we performed 22 automated erythrocyte depletions of BM for ABO mismatched BMT in 21 patients, 11 with the Amicus (A; 10 patients) and 11 with the CS3000 (F; 11) device. RESULTS: There were no statistical differences in donor age, recipient age, type of ABO mismatch, and CD34+ cell yield [group A pre 7.03 post 4.93 vs. group F pre 8.55 and post 6.2 x 10E06 cells per kilogram of bodyweight] for both devices. The efficiency for the CD34+ cell collection was lower, but not statistically significant, in the Amicus device (70% +/- 12 vs. 84% +/- 12; U-test P = 0.123). The erythrocyte volume in the final product was higher but not statistically significant different in the Amicus device (9.46 +/- 2.3 vs. 6.98 +/- 3.3 ml; U-test P = 0.17). During the evaluation period, no technical problems were observed. All patients but one, who died at d + 11, showed a sustained engraftment. CONCLUSIONS: We conclude that, in principle, the Amicus device can be used for MNC collection from BM to deplete erythrocytes from BM grafts in allogeneic stem cell transplantations.
机译：ABO不相容的骨髓移植（BMT）需要处理捐赠的骨髓（BM），即红细胞耗竭或体积减小。 AMICUS系统被引入外周血单核细胞收集领域，在效率和安全性方面表现出良好的性能。为了评估Amicus设备用于BM的MNC收集程序的性能，我们分析了从Amicus和Fenwal CS3000omnix plus设备获得的数据。方法：从2005年至2008年，我们对21例患者进行了22例针对ABO不匹配BMT的BM的自动红细胞清除，其中11例使用Amicus（A; 10例），另11例使用CS3000（F; 11）。结果：两种装置的供体年龄，受体年龄，ABO错配类型和CD34 +细胞产量均无统计学差异[A组7.03后4.93后vs F组8.55前每千克体重6.2 x 10E06细胞] 。在Amicus设备中，收集CD34 +细胞的效率较低，但没有统计学意义（70％+/- 12对84％+/- 12; U检验P = 0.123）。最终产品中的红细胞体积较高，但在Amicus装置中无统计学差异（9.46 +/- 2.3与6.98 +/- 3.3 ml; U检验P = 0.17）。在评估期间，未发现任何技术问题。除一名患者外，所有患者均在d + 11时死亡，表现出持续的植入。结论：我们得出的结论是，原则上，Amicus设备可用于从异体干细胞收集MNC，以耗尽同种异体干细胞移植中的BM移植物中的红细胞。

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