A Dendritic Cell Vaccine Pulsed with Autologous Hypochlorous Acid-Oxidized Ovarian Cancer Lysate Primes Effective Broad Antitumor Immunity: From Bench to Bedside

Chiang Cheryl Lai-Lai; Kandalaft Lana E.; Tanyi Janos; Hagemann Andrea R.; Motz Gregory T.; Svoronos Nikolaos; Montone Kathleen; Mantia-Smaldone Gina M.; Smith Lori; Nisenbaum Harvey L.; Levine Bruce L.; Kalos Michael; Czerniecki Brian J.; Torigian Drew A.; Powell Daniel J. Jr.; Mick Rosemarie; Coukos George

首页> 外文期刊>Clinical cancer research: an official journal of the American Association for Cancer Research >A Dendritic Cell Vaccine Pulsed with Autologous Hypochlorous Acid-Oxidized Ovarian Cancer Lysate Primes Effective Broad Antitumor Immunity: From Bench to Bedside

【24h】

A Dendritic Cell Vaccine Pulsed with Autologous Hypochlorous Acid-Oxidized Ovarian Cancer Lysate Primes Effective Broad Antitumor Immunity: From Bench to Bedside

机译：自体次氯酸氧化的卵巢癌裂解液脉冲的树突状细胞疫苗可引发有效的广泛抗肿瘤免疫力：从长凳到床边

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Purpose: Whole tumor lysates are promising antigen sources for dendritic cell (DC) therapy as they contain many relevant immunogenic epitopes to help prevent tumor escape. Two common methods of tumor lysate preparations are freeze-thaw processing and UVB irradiation to induce necrosis and apoptosis, respectively. Hypochlorous acid (HOCl) oxidation is a new method for inducing primary necrosis and enhancing the immunogenicity of tumor cells.

机译：目的：完整的肿瘤裂解物是树突状细胞（DC）治疗的有希望的抗原来源，因为它们含有许多相关的免疫原性表位，有助于防止肿瘤逃逸。两种常用的肿瘤溶解产物制备方法是冻融处理和UVB照射，分别诱导坏死和凋亡。次氯酸（HOCl）氧化是诱导原发性坏死和增强肿瘤细胞免疫原性的新方法。

著录项

来源
《Clinical cancer research: an official journal of the American Association for Cancer Research》 |2013年第17期|共15页
作者
Chiang Cheryl Lai-Lai; Kandalaft Lana E.; Tanyi Janos; Hagemann Andrea R.; Motz Gregory T.; Svoronos Nikolaos; Montone Kathleen; Mantia-Smaldone Gina M.; Smith Lori; Nisenbaum Harvey L.; Levine Bruce L.; Kalos Michael; Czerniecki Brian J.; Torigian Drew A.; Powell Daniel J. Jr.; Mick Rosemarie; Coukos George;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类肿瘤学;
关键词

相似文献

外文文献
专利

1. A Dendritic Cell Vaccine Pulsed with Autologous Hypochlorous Acid-Oxidized Ovarian Cancer Lysate Primes Effective Broad Antitumor Immunity: From Bench to Bedside [J] . Chiang Cheryl Lai-Lai, Kandalaft Lana E., Tanyi Janos, Clinical cancer research: an official journal of the American Association for Cancer Research . 2013,第17期

机译：自体次氯酸氧化的卵巢癌裂解液脉冲的树突状细胞疫苗可引发有效的广泛抗肿瘤免疫力：从长凳到床边
2. A Phase I vaccine trial using dendritic cells pulsed with autologous oxidized lysate for recurrent ovarian cancer [J] . Lana E Kandalaft, Cheryl L Chiang, Janos Tanyi, Journal of Translational Medicine . 2013,第1期

机译：一期使用自体氧化裂解物脉冲的树突状细胞治疗复发性卵巢癌的疫苗试验
3. A Phase I vaccine trial using dendritic cells pulsed with autologous oxidized lysate for recurrent ovarian cancer [J] . Lana E Kandalaft, Cheryl L Chiang, Janos Tanyi, Journal of Translational Medicine . 2013,第1期

机译：一期使用自体氧化裂解物脉冲的树突状细胞治疗复发性卵巢癌的疫苗试验
4. Clinical Outcome of Breast and Ovarian Cancer Patients Treated after High-Dose Chemotherapy and Autologous Stem Cell Rescue with Theratope (STn-KLH) Cancer Vaccine: Theratope (STn-KLH) Cancer Vaccine following Autologous Transplant [C] . Leona A. Holmberg, Katherine A. Guthrie, Brenda M. Sandmaier Chemical glycobiology . -1

机译：大剂量化学疗法和自体干细胞拯救治疗的Theratope（STn-KLH）癌症疫苗治疗的乳腺癌和卵巢癌患者的临床结果：自体移植后的Theratope（STn-KLH）癌症疫苗
5. Genetically Stable Poliovirus Vectors Activate Dendritic Cells and Prime Antitumor CD8 T Cell Immunity [D] . Mosaheb, Mohammad Mubeen. 2019

机译：基因稳定的脊髓灰质血病毒载体激活树突细胞和抗肿瘤CD8 T细胞免疫力
6. A Dendritic Cell Vaccine Pulsed with Autologous HypochlorousAcid-Oxidized Ovarian Cancer Lysate Primes Effective Broad Antitumor Immunity:From Bench to Bedside [O] . Cheryl Lai-Lai Chiang, Lana E. Kandalaft, Janos Tanyi, -1

机译：自体次氯酸脉冲树突状细胞疫苗酸氧化卵巢癌裂解液可引发有效的广泛抗肿瘤免疫力：从长凳到床头
7. A dendritic cell vaccine pulsed with autologous hypochlorous Acid-oxidized ovarian cancer lysate primes effective broad antitumor immunity: from bench to bedside. [O] . Chiang, C.L., Kandalaft, L.E., Tanyi, J., 2013

机译：用自体次氯酸脉冲氧化的卵巢癌裂解物脉冲的树突状细胞疫苗可有效地发挥广泛的抗肿瘤免疫力：从长凳到床边。

A Dendritic Cell Vaccine Pulsed with Autologous Hypochlorous Acid-Oxidized Ovarian Cancer Lysate Primes Effective Broad Antitumor Immunity: From Bench to Bedside

摘要

著录项

相似文献

相关主题

期刊订阅