...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of computer assisted tomography >Computed tomography perfusion of squamous cell carcinoma of the upper aerodigestive tract. Initial results.
【24h】

Computed tomography perfusion of squamous cell carcinoma of the upper aerodigestive tract. Initial results.

机译：上消化道鳞状细胞癌的计算机断层扫描灌注。初步结果。

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE: To define the computed tomography (CT) perfusion characteristics of head and neck squamous cell carcinoma. METHODS: Fourteen consecutive patients with untreated squamous cell cancers of head and neck underwent CT of the head and neck along with CT perfusion imaging through the primary site. For the perfusion studies, CT density changes in blood and tissues were kinetically analyzed using the commercially available CT Perfusion 2 software (General Electric Medical Systems. Milwaukee, WI) on a GE Advantage Windows workstation. This yielded parameter maps of fractional tissue blood volume (mL/100 g), blood flow (mL x 100 g(-1) x min(-1)), mean transit time (s), and microvascular permeability surface area product (mL x 100 g(-1) x min(-1)). One head and neck radiologist analyzed perfusion data. Regions of interest (ROI) were placed over the primary tumor site, tongue base, and adjacent muscle groups. The average values of tissue blood volume (BV), blood flow (BF), mean transit time (MTT), and capillary permeability surface area product (CP) were then calculated for the tumor and compared with the average values for the tongue base and adjacent musculature. To determine a statistically significant difference between the tumor and muscle parameters, the Wilcoxon sign test, a nonparametric test for paired data, was employed. RESULTS: The average values of CP, BF, and BV were higher in primary tumor (41.9, 132.9, 6.2, respectively) than in tongue base or adjacent muscular structures. The MTT was reduced in primary tumors (4.0) compared with adjacent normal structures. The above differences were statistically significant (P<0.05). CONCLUSIONS: We obtained baseline perfusion data for head and neck squamous cell cancers and compared it with adjacent normal structures. Our initial results suggest that CT perfusion parameters (CP, BF, BV, and MTT) can be used to help differentiate head and neck squamous cell carcinoma (SCCA) from adjacent normal tissue.
机译：目的：确定头颈部鳞状细胞癌的计算机断层扫描（CT）灌注特征。方法：连续14例未经治疗的头颈部鳞状细胞癌患者接受了头颈部CT扫描，并通过主要部位进行了CT灌注成像。对于灌注研究，使用市售的CT Perfusion 2软件（General Electric Medical Systems，密尔沃基，威斯康星州）在GE Advantage Windows工作站上动力学分析血液和组织中的CT密度变化。这样就产生了部分组织血容量（mL / 100 g），血流量（mL x 100 g（-1）x min（-1）），平均通过时间（s）和微血管通透性表面积乘积（mL）的参数图x 100 g（-1）x min（-1））。一位头颈放射科医生分析了灌注数据。将感兴趣区域（ROI）放在原发肿瘤部位，舌根和邻近的肌肉群上。然后计算肿瘤的组织血容量（BV），血流量（BF），平均通过时间（MTT）和毛细血管通透性表面积乘积（CP）的平均值，并与舌根和舌根的平均值进行比较。邻近的肌肉组织。为了确定肿瘤和肌肉参数之间的统计学显着差异，采用了Wilcoxon符号检验，这是配对数据的非参数检验。结果：原发肿瘤中CP，BF和BV的平均值高于舌根或邻近肌肉结构中的平均值（分别为41.9、132.9、6.2）。与邻近的正常结构相比，原发性肿瘤的MTT降低了（4.0）。上述差异具有统计学意义（P <0.05）。结论：我们获得了头颈部鳞状细胞癌的基线灌注数据，并将其与邻近的正常结构进行了比较。我们的初步结果表明，CT灌注参数（CP，​​BF，BV和MTT）可用于帮助将头颈部鳞状细胞癌（SCCA）与相邻的正常组织区分开。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号