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首页> 外文期刊>Journal of computer assisted tomography >Magnetic resonance imaging and spectroscopy of pilomyxoid astrocytomas: case reports and comparison with pilocytic astrocytomas.
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Magnetic resonance imaging and spectroscopy of pilomyxoid astrocytomas: case reports and comparison with pilocytic astrocytomas.

机译：绒毛状星形细胞瘤的磁共振成像和光谱学：病例报告和与细胞性星形细胞瘤的比较。

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BACKGROUND AND PURPOSE: Pilomyxoid astrocytomas (PMAs) have been described only recently. They appear as low-grade tumors sharing imaging features similar to pilocytic astrocytomas (PAs). However, pilomyxoid astrocytomas have different histological features and behave more aggressively than PAs. We present the imaging and proton spectroscopic (magnetic resonance spectroscopy; MRS) findings in 3 patients with PMA and compare them with those of PA arising in other sites. METHODS: Three patients who later proved to harbor PMA were studied with MR imaging and multivolume MRS. We analyzed the imaging findings, with attention to location, size, signal intensities, pattern of enhancement, and edema. In addition, we analyzed the MRS, with attention to the peaks of choline (Cho), creatine (Cr), N-acetyl aspartate, lipids, lactate, and myoinositol, and ratios between these metabolites. We compared the MRS studies of PMA with those of PA located in the hypothalamus and brain stem. RESULTS: In 2 patients, the PMAswere located in the chiasmatic-hypothalamic and third-ventricular-hypothalamic regions, showing solid enhancement, high T2 signal intensity, and hydrocephalus. One PMA was found in the right parietal lobe showing a well-defined mass without enhancement and high T2 signal intensity. The 2 PMAs showed high Cho/Cr ratios in peritumoral regions at long echo time in comparison with PA. A third PMA showed slight elevation of Cho/Cr ratio in peritumoral regions and no elevation of Cho/Cr ratios within the mass when compared with a PA. Short echo time MRS obtained in 2 PMAs showed low myoinositol/Cr ratios in tumoral regions in comparison with PA. CONCLUSIONS: Our 2 PMAs showed imaging features similar to those described in the literature. Magnetic resonance spectroscopy showed elevated Cho/Cr outside their enhancing margins, which may be related to their more aggressive behavior when compared with PA. The third PMA was different to those previously reported in the literature because it was hemispheric rather than hypothalamic in location in addition to having low intratumoral ratios of Cho/Cr.
机译：背景与目的：恶性胶质细胞星形细胞瘤（PMA）只是最近才被描述。它们表现为低级肿瘤，具有类似于毛细胞星形细胞瘤（PA）的影像学特征。但是，绒毛状星形细胞瘤具有不同的组织学特征，并且比PA更具侵略性。我们介绍了3例PMA患者的影像学和质子能谱（磁共振波谱; MRS）发现，并将其与其他部位的PA进行了比较。方法：对三名后来证实患有PMA的患者进行了MR成像和多体积MRS研究。我们分析了影像学发现，并注意其位置，大小，信号强度，增强模式和水肿。此外，我们分析了MRS，并注意了胆碱（Cho），肌酸（Cr），N-乙酰天门冬氨酸，脂质，乳酸盐和肌醇的峰，以及这些代谢物之间的比率。我们将PMA与位于下丘脑和脑干的PA的MRS研究进行了比较。结果：2例患者的PMAs位于下丘脑下丘脑区和下丘脑第三脑区，表现为固体增强，高T2信号强度和脑积水。在右顶叶中发现了一种PMA，显示出明确的肿块，没有增强，T2信号强度也很高。与PA相比，在较长的回波时间，2 PMA在肿瘤周围区域显示出较高的Cho / Cr比。与PA相比，第三个PMA显示肿瘤周围区域的Cho / Cr比略有升高，而肿块内的Cho / Cr比没有升高。与PA相比，在2个PMA中获得的短回波时间MRS显示出较低的肿瘤区域肌醇/ Cr比。结论：我们的2个PMA的成像特征与文献中描述的相似。磁共振波谱显示在增强边缘以外的Cho / Cr升高，与PA相比，这可能与其更具侵略性。第三个PMA与先前文献中报道的PMA不同，因为它的位置是半球状而不是下丘脑，而且肿瘤内的Cho / Cr比率很低。

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