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首页> 外文期刊>Journal of computer assisted tomography >Proton magnetic resonance spectroscopy of the hippocampus in patients with mild cognitive impairment: a pilot study.
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Proton magnetic resonance spectroscopy of the hippocampus in patients with mild cognitive impairment: a pilot study.

机译：轻度认知障碍患者海马质子磁共振波谱：一项前瞻性研究。

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OBJECTIVE: To assess the brain metabolites in the hippocampus of patients with mild cognitive impairment (MCI) using proton magnetic resonance spectroscopy at 0.5 T. METHODS: Absolute concentrations and ratios to creatine of N-acetyl aspartate, myoinositol, glutamate + glutamine, and choline were measured in the right and left hippocampus of 5 MCI patients and 5 control subjects. RESULTS: In MCI subjects, reduced N-acetyl aspartate was found in the right hippocampus (P = 0.01), and increased myoinositol was found in the left hippocampus (P = 0.02). Myoinositol/N-acetyl aspartate ratios were higher in the right (P = 0.03) and left (P = 0.01) hippocampus of MCI subjects. No significant difference in the concentration of glutamate + glutamine was observed between the control and MCI groups. CONCLUSIONS: An increase in myoinositol and a decrease in N-acetyl aspartate may be observed in the preclinical stages of dementia. Ratio measurements of these metabolites may serve as a biomarker for MCI.
机译：目的：使用质子磁共振波谱在0.5 T下评估轻度认知障碍（MCI）患者海马中的脑代谢产物。在5名MCI患者和5名对照受试者的左右海马区进行了测量。结果：在MCI受试者中，右海马体中N-乙酰天门冬氨酸减少（P = 0.01），左海马体中肌醇增加（P = 0.02）。 MCI受试者海马的肌醇/ N-乙酰天门冬氨酸比率较高（P = 0.03）和左侧（P = 0.01）。在对照组和MCI组之间，未观察到谷氨酸+谷氨酰胺浓度的显着差异。结论：在痴呆症的临床前阶段，肌醇增加，N-乙酰天门冬氨酸减少。这些代谢物的比率测量可以用作MCI的生物标记。

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