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首页> 外文期刊>Journal of clinical laboratory analysis. >Comparative evaluation of a new chemiluminiscent assay and an ELISA for the detection of IgM against measles
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Comparative evaluation of a new chemiluminiscent assay and an ELISA for the detection of IgM against measles

机译：新型化学发光检测法和ELISA检测麻疹IgM的比较评估

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Background: The primary test for the laboratory confirmation of measles is immunoglobulin M (IgM) serology. It is therefore important to evaluate new commercial measles IgM immunoassays to ensure high-quality measles diagnostic testing. The purpose of this study was to evaluate the diagnostic performance of LIAISON IgM measles (DiaSorin, Saluggia, Italy), a new automated chemiluminescence immunoassay (CLIA), in comparison with enzyme immunoassay (EIA) Enzygnost (Siemens, Marburg, Germany). Methods: Sensitivity was examined using a panel of measles laboratory confirmed sera; specificity was addressed by testing sera from healthy populations and subjects with infections that may interfere with measles IgM serology. Results: The diagnostic performances of the two assays were very similar: both Enzygnost EIA and LIAISON CLIA performed with a sensitivity of 93.7% and 98.8%, whereas the specificity was 96.8% and 97.9%, respectively. Conclusion: We concluded that LIAISON IgM measles can be a good alternative to the other immunoassay for laboratory measles confirmation.
机译：背景：用于实验室确认麻疹的主要测试是免疫球蛋白M（IgM）血清学。因此，重要的是评估新的商业性麻疹IgM免疫测定，以确保高质量的麻疹诊断测试。这项研究的目的是评估与酶免疫法（EIA）Enzygnost（Siemens，Marburg，德国）相比，新型自动化学发光免疫分析法（CLIA）LIAISON IgM麻疹（DiaSorin，意大利萨鲁贾）的诊断性能。方法：使用一组麻疹实验室确诊的血清检查敏感性。通过检测健康人群和感染可能会干扰麻疹IgM血清学的受试者的血清来解决特异性。结果：两种测定的诊断性能非常相似：Enzygnost EIA和LIAISON CLIA的灵敏度均为93.7％和98.8％，而特异性分别为96.8％和97.9％。结论：我们得出结论，LIAISON IgM麻疹可以替代其他免疫测定，用于实验室麻疹确诊。

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