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首页> 外文期刊>Journal of computer assisted tomography >Necrosis degree displayed in computed tomography images correlated with hypoxia and angiogenesis in breast cancer
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Necrosis degree displayed in computed tomography images correlated with hypoxia and angiogenesis in breast cancer

机译：在计算机断层扫描图像中显示的坏死程度与乳腺癌的缺氧和血管生成有关

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OBJECTIVE: The objective of this study was to investigate the correlation between the degree of necrosis displayed in computed tomography (CT) image and the expression of hypoxic and angiogenesis biomarkers of breast cancer. METHODS: Forty-four breast cancer cases were examined with CT before surgery. Tumor specimen expressions of glucose transporter 1 (Glut1), hypoxia-inducible factor 1α (HIF-1α), carbonic anhydrase IX (CA IX), vascular endothelial growth factor (VEGF), and CD34 (as a marker of vascular endothelial cells) were detected by immunohistochemistry. RESULTS: The expressions of Glut1 and CA IX were localized primarily to the edges of necrotic areas or intraduct surface; there was a strong correlation between HIF-1α-positive expression and CA IX-positive expression (P < 0.001), and higher Glut1 or CA IX expression grade was associated with lower microvessel density (MVD) value. In CT enhanced images, lower relative CT (rCT) values were associated with more significant necrosis in the tumor; rCT value correlated positively with MVD significantly (r = 0.319, P = 0.035), and higher Glut1 or CA IX expression grade correlated with lower rCT values (P = 0.001 and 0.003, respectively). Although high VEGF expression was significantly correlated with high HIF-1α expression (P < 0.001), there were no correlations between VEGF and MVD, and HIF-1α and MVD (P = 0.559 and 0.710, respectively), and the difference of the mean rCT value between high VEGF or HIF-1α expression group and low VEGF or HIF-1α expression group was not significant. CONCLUSIONS: In breast cancer tissues, Glut1 and CA IX are key hypoxia biomarkers. Importantly, detection of necrosis in breast cancer tissue via CT enhanced imaging may prognosticate hypoxia and angiogenesis status and help to determine treatment plan of advanced breast cancer.
机译：目的：本研究旨在探讨计算机断层扫描（CT）图像中显示的坏死程度与乳腺癌低氧和血管生成生物标志物的表达之间的相关性。方法：对44例乳腺癌患者进行术前CT检查。葡萄糖转运蛋白1（Glut1），缺氧诱导因子1α（HIF-1α），碳酸酐酶IX（CA IX），血管内皮生长因子（VEGF）和CD34（作为血管内皮细胞的标志物）的肿瘤标本表达为通过免疫组织化学检测。结果：Glut1和CA IX的表达主要定位于坏死区域的边缘或管内表面。 HIF-1α阳性表达与CA IX阳性表达之间有很强的相关性（P <0.001），较高的Glut1或CA IX表达等级与较低的微血管密度（MVD）值相关。在CT增强图像中，较低的相对CT（rCT）值与肿瘤中更严重的坏死有关。 rCT值与MVD呈显着正相关（r = 0.319，P = 0.035），较高的Glut1或CA IX表达等级与较低的rCT值相关（分别为P = 0.001和0.003）。尽管高VEGF表达与高HIF-1α表达显着相关（P <0.001），但VEGF与MVD，HIF-1α与MVD之间无相关性（分别为P = 0.559和0.710），且均值差异高VEGF或HIF-1α表达组与低VEGF或HIF-1α表达组之间的rCT值不显着。结论：在乳腺癌组织中，Glut1和CA IX是关键的低氧生物标志物。重要的是，通过CT增强成像检测乳腺癌组织中的坏死可能预后缺氧和血管生成状态，并有助于确定晚期乳腺癌的治疗计划。

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