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首页> 外文期刊>Journal of clinical laboratory analysis. >The Differential Diagnostic Value of Serum NT-proBNP in Hospitalized Patients of Heart Failure With Pneumonia
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The Differential Diagnostic Value of Serum NT-proBNP in Hospitalized Patients of Heart Failure With Pneumonia

机译：血清NT-proBNP在住院心衰性肺炎患者中的鉴别诊断价值

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Serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) is considered as an effective predictor for patients with heart failure (HF), while a strong body of evidence has found its utility in inflammatory diseases. It is difficult to differentiate HF and HF coexisting with other inflammations by measuring NT-proBNP. The aim of this study was to estimate the differential diagnostic performance of serum NT-proBNP in hospitalized HF patients with pneumonia. A prospective study was launched. Sixty nine HF patients, 51 HF patients complicated with pneumonia, and 38 patients with pneumonia were enrolled. Serum NT-proBNP levels were measured on Roche Elecsys. X-ray and the European Society of Cardiology (ESC) diagnostic principles were adopted to identify patients with pneumonia and HF, respectively. The diagnostic performance of NT-proBNP was assessed by ROC. Serum NT-proBNP [7,039(1,008-24,672) pg/ml] in patients of HF complicated with pneumonia was significantly higher than that in those of patients with single HF [3,147(616-24,062) pg/ml] or single pneumonia [911(98-3,812) pg/ml] (P < 0.0001). No correlation was found between the level of NT-proBNP and hospital stay. The area under ROC curve (AUC) of NT-proBNP for distinguishing patients of HF with pneumonia was 0.8082. At the level of 4,691 pg/ml, the optimal cutoff value, 74.5% sensitivity and 81.8% specificity of NT-proBNP were predicted. Evaluation of serum NT-proBNP is conducive for clinicians to identify patients of HF with pneumonia, but its poor efficacy in monitoring the curative therapy in this entire cohort is not recommended.
机译：血清N端前B型利钠尿肽（NT-proBNP）被认为是心力衰竭（HF）患者的有效预测指标，而有强有力的证据表明其可用于炎症性疾病。通过测量NT-proBNP很难区分HF和与其他炎症共存的HF。这项研究的目的是评估血清NT-proBNP在住院的HF肺炎患者中的鉴别诊断性能。开展了一项前瞻性研究。入选了69例HF患者，51例并发肺炎的HF患者和38例肺炎的患者。在Roche Elecsys上测量血清NT-proBNP水平。 X射线和欧洲心脏病学会（ESC）的诊断原则分别用于识别肺炎和HF患者。通过ROC评估NT-proBNP的诊断性能。 HF合并肺炎患者的血清NT-proBNP [7,039（1,008-24,672）pg / ml]显着高于单HF [3,147（616-24,062）pg / ml]或单一肺炎[911]的患者（98-3,812）pg / ml]（P <0.0001）。在NT-proBNP水平和住院时间之间未发现相关性。 NT-proBNP的ROC曲线下面积（AUC）用于区分HF并发肺炎。在4,691 pg / ml的水平上，预测了NT-proBNP的最佳临界值，74.5％的灵敏度和81.8％的特异性。血清NT-proBNP的评估有助于临床医生识别HF并发肺炎的患者，但不建议在整个队列中监测其疗效的不良疗效。

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