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首页> 外文期刊>Journal of clinical biochemistry and nutrition. >Aegle marmelos fruit extract attenuates isoproterenol-induced oxidative stress in rats
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Aegle marmelos fruit extract attenuates isoproterenol-induced oxidative stress in rats

机译：橘子果提取物减轻异丙肾上腺素诱导的大鼠氧化应激

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Myocardial infarction is a major public health concern and the leading cause of death throughout the world. The present study investigates the ability of Aegle marmelos fruit extract to prevent pathological changes and oxidative stress after isoproterenol induced myocardial infarction in rats. In vitro studies showed that Aegle marmelos fruit extract possesses antioxidant activity. Administration of isoproterenol (85 mg/kg body weight) to rats resulted in significantly elevated plasma transaminases, lactate dehydrogenase and creatine kinase, however, cardiac tissue analyses showed decreased activity of the above enzymes compared to experimental control rats. Further, isoproterenol administration significantly increased plasma and cardiac tissue thiobarbituric acid reactive substances and lowered the activities of cardiac tissue superoxide dismutase, catalase, reduced glutathione, glutathione peroxidase and glutathione-S-transferase when compared to control groups. Pretreatment with Aegle marmelos fruit extract at a dose of 150 mg/kg body weight for a period of 45 days significantly prevented the observed alterations. Our data suggest that Aegle marmelos fruit extract exerts its protective effect by decreasing thiobarbituric acid reactive substances and elevating antioxidants status in isoproterenol treated rats. Both biochemical and histopathological results in the isoproterenol-induced myocardial infarction model emphasize the beneficial action of Aegle marmelos fruit extract as a cardioprotective agent.
机译：心肌梗塞是主要的公共卫生问题，也是全世界死亡的主要原因。本研究调查了马格洛斯水果提取物预防异丙肾上腺素诱发的大鼠心肌梗死后病理变化和氧化应激的能力。体外研究表明，Aegle marmelos水果提取物具有抗氧化活性。给大鼠服用异丙肾上腺素（85 mg / kg体重）会导致血浆转氨酶，乳酸脱氢酶和肌酸激酶显着升高，但是，心脏组织分析显示，与实验对照组相比，上述酶的活性降低。此外，与对照组相比，异丙肾上腺素的给药显着增加了血浆和心脏组织中的硫代巴比妥酸反应性物质，并降低了心脏组织中的超氧化物歧化酶，过氧化氢酶，谷胱甘肽，谷胱甘肽过氧化物酶和谷胱甘肽-S-转移酶的活性。以150 mg / kg体重的Aegle marmelos水果提取物预处理45天，可显着防止观察到的变化。我们的数据表明，Aegle marmelos水果提取物通过减少硫代巴比妥酸反应性物质并提高异丙肾上腺素治疗的大鼠的抗氧化剂状态而发挥其保护作用。异丙肾上腺素诱发的心肌梗塞模型的生化和组织病理学结果都强调了马eg果果实提取物作为心脏保护剂的有益作用。

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