EGG YOLK RIBOFLAVIN BINDING PROTEIN AS A NEW CHIRAL STATIONARY PHASE IN HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY

Massolini G.; Ponci MC.; Gandini C.; Caccialanza G.; Monaco HL.; Delorenzi E.

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EGG YOLK RIBOFLAVIN BINDING PROTEIN AS A NEW CHIRAL STATIONARY PHASE IN HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY

机译：鸡蛋黄核黄素结合蛋白是高效液相色谱中一种新的手性固定相

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A chiral stationary phase for high-performance liquid chromatography based on hen egg yolk riboflavin binding protein is introduced. The purified protein was immobilized on activated 5NH(2) Nucleosil silica. Chiral acidic, basic and uncharged drugs were chromatographed and the influence of the mobile phase parameters on the retention times and enantioselectivity was studied. Thirteen out of the twenty compounds tested were partially or baseline resolved. These encouraging preliminary results suggest that this chiral stationary phase may be applicable to a wide range of drug enantiomers in the reversed-phase mode. [References: 13]

机译：介绍了一种基于蛋黄核黄素结合蛋白的高效液相色谱手性固定相。纯化的蛋白质固定在活化的5NH（2）Nucleosil二氧化硅上。对手性酸性，碱性和不带电荷的药物进行了色谱分析，研究了流动相参数对保留时间和对映选择性的影响。测试的二十种化合物中有十三种已部分或基线分离。这些令人鼓舞的初步结果表明，该手性固定相可以在反相模式下适用于多种药物对映体。 [参考：13]

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《Journal of chromatography, A: Including electrophoresis and other separation methods》 |1995年第1期|共11页
作者
Massolini G.; Ponci MC.; Gandini C.; Caccialanza G.; Monaco HL.; Delorenzi E.;
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正文语种 eng
中图分类仪器分析法（物理及物理化学分析法）;
关键词
Alpha-1-acid glycoprotein; Optical resolution; Serum-albumin; Column; Drugs; Separation;

机译：α1-酸糖蛋白光学拆分血清白蛋白柱药物分离;

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1. EGG YOLK RIBOFLAVIN BINDING PROTEIN AS A NEW CHIRAL STATIONARY PHASE IN HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY [J] . Massolini G., Ponci MC., Gandini C., Journal of chromatography, A: Including electrophoresis and other separation methods . 1995,第1期

机译：鸡蛋黄核黄素结合蛋白是高效液相色谱中一种新的手性固定相
2. Chromatographic investigation on the binding site characteristics of quail egg-white riboflavin binding protein as a chiral stationary phase [J] . Massolini G., Calleri E., Tabolotti E., Journal of Chromatography, Biomedical Applications . 2000,第2期

机译：鹌鹑蛋清核黄素结合蛋白作为手性固定相的结合位点特征的色谱研究
3. A novel preparative method for the isolation of avidin and riboflavin-binding glycoprotein from chicken egg-white by the use of high-performance liquid chromatography [J] . A G Gabibov, A G Rabinkov, A M Shuster, The biochemical journal . 1990,第1期

机译：高效液相色谱法从鸡蛋白中分离抗生物素蛋白和核黄素结合糖蛋白的新型制备方法
4. Chromatographic chiral separation on chiral stationary phase by HPLC: Cellulose 4-methylbenzoate beads as chiral stationary phase for chiral separation of some racemates by high performance liquid chromatography [C] . Han Xiaoqian, Zhang Dabing, Liu Wanliang, 2011 International Conference on Consumer Electronics, Communications and Networks . 2011

机译：HPLC在手性固定相上进行色谱手性分离：以4-甲基苯甲酸纤维素微珠为手性固定相，通过高效液相色谱手性分离某些外消旋体
5. The use of liquid chromatography and subcritical fluid chromatography for chiral separations using macrocyclic chiral stationary phases: Insights into mechanisms of retention and chiral discrimination [D] . Woods, Ross Michael. 2014

机译：液相色谱和亚临界流体色谱在使用大环手性固定相进行手性分离中的应用：洞察保留和手性区分的机理
6. A novel preparative method for the isolation of avidin and riboflavin-binding glycoprotein from chicken egg-white by the use of high-performance liquid chromatography. [O] . V E Piskarev, A M Shuster, A G Gabibov, 1990

机译：一种通过高效液相色谱从鸡蛋白中分离抗生物素蛋白和核黄素结合糖蛋白的新型制备方法。
7. A novel preparative method for the isolation of avidin and riboflavin-binding glycoprotein from chicken egg-white by the use of high-performance liquid chromatography. [O] . Piskarev, V E, Shuster, A M, Gabibov, A G, 1990

机译：一种通过高效液相色谱从鸡蛋白中分离抗生物素蛋白和核黄素结合糖蛋白的新型制备方法。

EGG YOLK RIBOFLAVIN BINDING PROTEIN AS A NEW CHIRAL STATIONARY PHASE IN HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY

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