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首页> 外文期刊>Journal of chromatography, B. Analytical technologies in the biomedical and life sciences >Serum metabonomics study of anti-depressive effect of Xiao-Chai-Hu-Tang on rat model of chronic unpredictable mild stress
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Serum metabonomics study of anti-depressive effect of Xiao-Chai-Hu-Tang on rat model of chronic unpredictable mild stress

机译：小柴胡汤抗慢性不可预测轻度应激大鼠模型抗抑郁作用的血清代谢组学研究

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Xiao-Chai-Hu-Tang (XCHT) has been proven to be effective for the clinical treatment of depression. However, the mechanisms of definite antidepressant-like effects and detailed metabolic biomarkers were still unclear in this prior study. Here, we have investigated the metabolic profiles and potential biomarkers in a chronic unpredictable mild stress model after treatment with XCHT. Metabonomics based on ultra-high performance liquid chromatography coupled with mass spectrometry was used to profile the metabolic fingerprints of serum obtained from a rat model with chronic unpredictable mild stress with and without XCHT treatment. The model rats showed a significant decrease in sucrose preference and food consumption, and these depression-like symptoms were significantly improved by XCHT. Through principal component analysis (PCA), nine potential biomarkers of tryptophan, uric acid, phenylalanine, cholic acid and lysophosphatidylcholine (C18:0 LPC, C16:0 LPC, C16:1 LPC, C18:1 LPC, C20:4 LPC) were characterized as potential biomarkers involved the pathogenesis of depression. The therapeutic effect of XCHT on depression may involve in amino acid metabolism, lipid metabolism, oxidative stress and inflammation response. The present investigation highlights that metabonomics is a valuable tool for studying the essence of depression as well as evaluating the efficacy of the corresponding drug treatment. (C) 2016 Elsevier B.V. All rights reserved.
机译：小柴胡汤（XCHT）已被证明可有效治疗抑郁症。但是，在这项先前的研究中，尚不清楚明确的抗抑郁药样作用机制和详细的代谢生物标志物。在这里，我们已经研究了XCHT治疗后慢性不可预测的轻度应激模型中的代谢谱和潜在的生物标志物。基于超高效液相色谱与质谱联用的代谢组学用于分析得自具有XCHT治疗和未经XCHT治疗的慢性不可预测轻度应激大鼠模型的血清代谢指纹图谱。模型大鼠显示出蔗糖偏爱和食物消耗的显着降低，并且XCHT显着改善了这些抑郁样症状。通过主成分分析（PCA），色氨酸，尿酸，苯丙氨酸，胆酸和溶血磷脂酰胆碱（C18：0 LPC，C16：0 LPC，C16：1 LPC，C18：1 LPC，C20：4 LPC）的九种潜在生物标记为特征为潜在的生物标志物涉及抑郁症的发病机理。 XCHT对抑郁症的治疗作用可能涉及氨基酸代谢，脂质代谢，氧化应激和炎症反应。本研究强调，代谢组学是研究抑郁症的本质以及评估相应药物治疗功效的宝贵工具。 （C）2016 Elsevier B.V.保留所有权利。

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