Chromatographic and mass spectrometric methods for quantitative determination of 3-nitrotyrosine in biological samples and their application to human samples

Henrik Ryberg; Kenneth Caidahl

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Chromatographic and mass spectrometric methods for quantitative determination of 3-nitrotyrosine in biological samples and their application to human samples

机译：色谱和质谱法定量测定生物样品中的3-硝基酪氨酸及其在人体样品中的应用

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摘要

The permanent modification of soluble and protein-associated tyrosine by nitration results in the formation of 3-nitrotyrosine, which can be used as a marker of “nitro-oxidative” damage to proteins. Based on the analysis of patient materials, over 40 different diseases and/or conditions have been linked to increased nitration of tyrosine. They include many cardiovascular diseases, conditions associated with immunological reactions and neurological diseases. In this article we review the existing chromatographic and mass spectrometric methods for quantitative measurements of 3-nitrotyrosine in different human biological samples including plasma, either from the free amino acid pool or from hydrolyzed proteins from different matrices.

机译：通过硝化作用对可溶性和蛋白质相关酪氨酸的永久修饰会导致形成3-硝基酪氨酸，可将其用作蛋白质“硝基氧化”损伤的标志。根据对患者材料的分析，已将40多种不同的疾病和/或状况与酪氨酸的硝化作用增加联系在一起。它们包括许多心血管疾病，与免疫反应有关的疾病和神经系统疾病。在本文中，我们回顾了现有的色谱和质谱方法，用于从游离氨基酸库或来自不同基质的水解蛋白中定量测定不同人类生物样品（包括血浆）中的3-硝基酪氨酸。

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《Journal of chromatography, B. Analytical technologies in the biomedical and life sciences》 |2007年第2期|共12页
作者
Henrik Ryberg; Kenneth Caidahl;
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正文语种 eng
中图分类生物化学技术;
关键词
Reviews; HPLC; Mass spectrometry; Plasma; Urine; Cerebrospinal fluid;

机译：综述;HPLC;质谱;血浆;尿液;脑脊液;

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1. Chromatographic and mass spectrometric methods for quantitative determination of 3-nitrotyrosine in biological samples and their application to human samples [J] . Henrik Ryberg, Kenneth Caidahl Journal of chromatography, B. Analytical technologies in the biomedical and life sciences . 2007,第1a2期

机译：色谱和质谱法定量测定生物样品中的3-硝基酪氨酸及其在人体样品中的应用
2. Validation and application of a liquid chromatographic-mass spectrometric method for determination of artesunate in pharmaceutical samples. [J] . Lindegardh N, Dondorp AM, Singhasivanon P, Journal of Pharmaceutical and Biomedical Analysis: An International Journal on All Drug-Related Topics in Pharmaceutical, Biomedical and Clinical Analysis . 2007,第1期

机译：液相色谱-质谱法测定药物样品中的青蒿琥酯的验证和应用。
3. N.P.J.a b Validation and application of a liquid chromatographic-mass spectrometric method for determination of artesunate in pharmaceutical samples [J] . Lindegardh N, Dondorp A.M, Singhasivanon P Journal of Pharmaceutical and Biomedical Analysis: An International Journal on All Drug-Related Topics in Pharmaceutical, Biomedical and Clinical Analysis . 2007,第1期

机译：N.P.J.a b液相色谱-质谱法测定药物样品中青蒿琥酯的方法的验证和应用
4. Important Method Development Aspects of a Restricted Access Media-Based Trap-and-Elute Liquid Chromatography-Mass Spectrometry Method for Determination of Estrogens in Biological Samples [C] . Barbora Papouskova, Hui Fan, Karel Lemr, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2013

机译：基于限制的接入介质的捕集液相色谱 - 质谱法的重要方法开发方面用于测定生物样品中雌激素的方法
5. Development of new sample preparation methodolgies for mass spectrometric analysis of biological compounds. [D] . Al-Talla, Zeyad Abdel-Halim. 2008

机译：开发用于生物化合物质谱分析的新样品制备方法。
6. Mass-spectrometric profiling of porphyrins in complex biological samples with fundamental toxicological and pharmacological applications [O] . Sarah A. Sullivan, Bennett R. Streit, Ethan L. Ferguson, -1

机译：复杂生物样品中卟啉的质谱分析具有基础毒理学和药理学应用
7. Fully automated method for the liquid chromatographic-tandem mass spectrometric determination of cyproterone acetate in human plasma using restricted access material for on-line sample clean-up. [O] . Christians, Benoit, Fillet, Marianne, Chiap, Patrice, 2004

机译：全自动液相色谱-串联质谱法测定人血浆中的醋酸环丙孕酮，使用受限进入的材料进行在线样品净化。
8. Analysis of Biologic Samples for Morphine and Morphine-Related Compounds by Gas Chromatographic-Mass Spectrometric Methods. [R] . Horning, E. C., Thenot, J. P., Horning, M. G. 1976

机译：气相色谱 - 质谱法分析吗啡和吗啡相关化合物的生物样品。

Chromatographic and mass spectrometric methods for quantitative determination of 3-nitrotyrosine in biological samples and their application to human samples

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