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首页> 外文期刊>Journal of clinical densitometry >Official Positions for FRAX(R) clinical regarding international differences from Joint Official Positions Development Conference of the International Society for Clinical Densitometry and International Osteoporosis Foundation on FRAX(R).
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Official Positions for FRAX(R) clinical regarding international differences from Joint Official Positions Development Conference of the International Society for Clinical Densitometry and International Osteoporosis Foundation on FRAX(R).

机译：有关国际差异的FRAX（R）临床的官方立场，来自国际临床密度测定学会和国际骨质疏松基金会关于FRAX（R）的联合官方立场发展会议。

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摘要

Osteoporosis is a serious worldwide epidemic. Increased risk of fractures is the hallmark of the disease and is associated with increased morbidity, mortality and economic burden. FRAX(R) is a web-based tool developed by the Sheffield WHO Collaborating Center team, that integrates clinical risk factors, femoral neck BMD, country specific mortality and fracture data and calculates the 10 year fracture probability in order to help health care professionals identify patients who need treatment. However, only 31 countries have a FRAX(R) calculator at the time paper was accepted for publication. In the absence of a FRAX(R) model for a particular country, it has been suggested to use a surrogate country for which the epidemiology of osteoporosis most closely approximates the index country. More specific recommendations for clinicians in these countries are not available. In North America, concerns have also been raised regarding the assumptions used to construct the US ethnic specific FRAX(R) calculators with respect to the correction factors applied to derive fracture probabilities in Blacks, Asians and Hispanics in comparison to Whites. In addition, questions were raised about calculating fracture risk in other ethnic groups e.g., Native Americans and First Canadians. In order to provide additional guidance to clinicians, a FRAX(R) International Task Force was formed to address specific questions raised by physicians in countries without FRAX(R) calculators and seeking to integrate FRAX(R) into their clinical practice. The main questions that the task force tried to answer were the following: The Task Force members conducted appropriate literature reviews and developed preliminary statements that were discussed and graded by a panel of experts at the ISCD-IOF joint conference. The statements approved by the panel of experts are discussed in the current paper.
机译：骨质疏松症是一种严重的世界性流行病。骨折的风险增加是该疾病的标志，并与发病率，死亡率和经济负担增加有关。 FRAX（R）是由谢菲尔德卫生组织合作中心团队开发的基于网络的工具，该工具整合了临床风险因素，股骨颈骨密度，特定国家的死亡率和骨折数据，并计算了10年骨折的可能性，以帮助医疗保健专业人员确定需要治疗的患者。但是，在论文被接受发表时，只有31个国家/地区拥有FRAX（R）计算器。在没有针对特定国家的FRAX（R）模型的情况下，建议使用替代国，其骨质疏松症的流行病学最接近指数国。没有针对这些国家/地区的临床医生的更具体建议。在北美，与白人相比，在构造美国族裔特定FRAX（R）计算器时所使用的校正因子也可引起关注，该校正因子用于得出黑人，亚裔和西班牙裔人的骨折概率。此外，对于计算其他种族群体（例如，美洲原住民和加拿大原住民）的骨折风险也提出了疑问。为了向临床医生提供更多指导，成立了FRAX®国际工作队，以解决在没有FRAX®计算器的国家中医师提出的具体问题，并寻求将FRAX®纳入他们的临床实践。工作队试图回答的主要问题如下：工作队成员进行了适当的文献回顾，并提出了初步声明，这些声明由ISCD-IOF联席会议的专家小组讨论和定级。本文件讨论了专家小组批准的声明。

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