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首页> 外文期刊>Journal of Controlled Release: Official Journal of the Controlled Release Society >Jet-induced skin puncture and its impact on needle-free jet injections: Experimental studies and a predictive model
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Jet-induced skin puncture and its impact on needle-free jet injections: Experimental studies and a predictive model

机译：喷射诱发的皮肤穿刺及其对无针喷射的影响：实验研究和预测模型

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摘要

Needle-free jet injections constitute an important method of drug delivery, especially for insulin and vaccines. This report addresses the mechanisms of interactions of liquid jets with skin. Liquid jets first puncture the skin to form a hole through which the fluid is deposited into skin. Experimental studies showed that the depth of the hole significantly affects drug delivery by jet injections. At a constant jet exit velocity and nozzle diameter, the hole depth increased with increasing jet volume up to an asymptotic value and decreased with increasing values of skin's uniaxial Young's modulus. A theoretical model was developed to predict the hole depth as a function of jet and skin properties. A simplified model was first verified with polyacrylamide gels, a soft material in which the fluid mechanics during hole formation is well understood. Prediction of the hole depth in the skin is a first step in quantitatively predicting drug delivery by jet injection. (c) 2005 Elsevier B.V. All rights reserved.
机译：无针喷射注射是一种重要的药物输送方法，尤其是对于胰岛素和疫苗。该报告阐述了液体喷射流与皮肤相互作用的机理。液体喷射器首先刺穿皮肤以形成孔，流体通过该孔沉积到皮肤中。实验研究表明，孔的深度显着影响通过喷射注射的药物输送。在恒定的射流出口速度和喷嘴直径下，孔深度随着射流量的增加而增加，直到渐近值，而随着皮肤单轴杨氏模量值的增加而减小。开发了理论模型来预测孔深与射流和蒙皮特性的关系。首先使用聚丙烯酰胺凝胶验证了简化模型，聚丙烯酰胺凝胶是一种软材料，可以很好地理解孔形成过程中的流体力学。预测皮肤中孔的深度是定量预测射流注射药物输送的第一步。 （c）2005 Elsevier B.V.保留所有权利。

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