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首页> 外文期刊>Journal of Controlled Release: Official Journal of the Controlled Release Society >Effects of ultrasound and sodium lauryl sulfate on the transdermal delivery of hydrophilic permeants: Comparative in vitro studies with full-thickness and split-thickness pig and human skin
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Effects of ultrasound and sodium lauryl sulfate on the transdermal delivery of hydrophilic permeants: Comparative in vitro studies with full-thickness and split-thickness pig and human skin

机译：超声波和月桂基硫酸钠对亲水性渗透剂的透皮递送的影响：猪和人皮肤全厚度和分开厚度的体外比较研究

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摘要

The simultaneous application of ultrasound and the surfactant sodium lauryl sulfate (referred to as US/SLS) to skin enhances transdermal drug delivery (TDD) in a synergistic mechanical and chemical manner. Since full-thickness skin (FTS) and split-thickness skin (STS) differ in mechanical strength, US/SLS treatment may have different effects on their transdermal transport pathways. Therefore, we evaluated STS as an alternative to the well-established US/SLS-treated FTS model for TDD studies of hydrophilic permeants. We utilized the aqueous porous pathway model to compare the effects of US/SLS treatment on the skin permeability and the pore radius of pig and human FTS and STS over a range of skin electrical resistivity values. Our findings indicate that the US/SLS-treated pig skin models exhibit similar permeabilities and pore radii, but the human skin models do not. Furthermore, the US/SLS-enhanced delivery of gold nanoparticles and quantum dots (two model hydrophilic macromolecules) is greater through pig STS than through pig FTS, due to the presence of less dermis that acts as an artificial barrier to macromolecules. In spite of greater variability in correlations between STS permeability and resistivity, our findings strongly suggest the use of 700 μm-thick pig STS to investigate the in vitro US/SLS-enhanced delivery of hydrophilic macromolecules.
机译：将超声波和表面活性剂月桂基硫酸钠（称为US / SLS）同时应用到皮肤上可以以协同的机械和化学方式增强透皮药物递送（TDD）。由于全层皮肤（FTS）和厚层皮肤（STS）的机械强度不同，因此US / SLS处理对其透皮运输途径的影响可能不同。因此，我们对亲水性渗透物的TDD研究进行了评估，将STS替代已建立的US / SLS处理的FTS模型。我们利用水性多孔途径模型比较了US / SLS处理在一定范围的皮肤电阻率值上对猪和人FTS和STS的皮肤渗透性和孔半径的影响。我们的发现表明，经US / SLS处理的猪皮肤模型显示出相似的渗透性和毛孔半径，而人类皮肤模型则没有。此外，通过猪STS进行的US / SLS增强的金纳米颗粒和量子点（两种模型亲水性大分子）的传递比通过猪FTS的传递要大，这是因为存在的真皮层较少，可作为大分子的人工屏障。尽管STS渗透率和电阻率之间的相关性存在较大差异，但我们的发现强烈建议使用700μm厚的猪STS来研究亲水性大分子的体外US / SLS增强递送。

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