A copper(II) complex of 1,4,7-triazacyclononane featuring acetate pendant: an efficient DNA cleavage agent

JING QIAN; LI-PING WANG; JIN-LEI TIAN

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A copper(II) complex of 1,4,7-triazacyclononane featuring acetate pendant: an efficient DNA cleavage agent

机译：1,4,7-三氮杂环壬烷铜（II）配合物，具有乙酸酯侧链：一种有效的DNA裂解剂

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A new water-soluble copper(II) complex, Cu(TACNA)Br . 0.375H_2O (1) [TACNA = 1,4,7-triazacyclononane-N-acetate], has been synthesized to serve as artificial nucleases. The X-ray crystal structure of 1 indicates that one bromide and an oxygen from acetate pendant coordinate to copper(II) in addition to the nitrogen atoms in the TACN macrocycle, resulting in a five-coordinate complex with square-pyramidal geometry. The interaction of 1 with calf thymus DNA (ct-DNA) has been investigated by UV absorption and fluorescence spectroscopies, and the mode of ct-DNA binding for 1 has been proposed. In the absence of external agents, supercoiled plasmid DNA cleavage by 1 was performed under aerobic condition;;the influences on DNA cleavage of different complex concentrations and reaction times were also studied. The cleavage of plasmid DNA likely involves oxidative mechanism.

机译：一种新型水溶性铜（II）配合物Cu（TACNA）Br。 0.375H_2O（1）[TACNA = 1,4,7-三氮杂环壬烷-N-乙酸盐]已合成为人工核酸酶。 X射线晶体结构为1表示，一个溴化物和一个来自乙酸酯侧基的氧除了在TACN大环中的氮原子外，还与铜（II）配位，从而形成了一个具有四角锥几何形状的五坐标配合物。通过紫外吸收和荧光光谱研究了1与小牛胸腺DNA（ct-DNA）的相互作用，并提出了ct-DNA与1的结合方式。在没有外部试剂的情况下，在有氧条件下进行超螺旋质粒DNA切割;研究了不同复合物浓度和反应时间对DNA切割的影响。质粒DNA的切割可能涉及氧化机制。

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《Journal of Coordination Chemistry》 |2012年第2期|共9页
作者
JING QIAN; LI-PING WANG; JIN-LEI TIAN;
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正文语种 eng
中图分类无机化学;
关键词
Copper(II) complex; 1; 4; 7-Triazacyclononane; DNA-binding; DNA cleavage;

机译：铜（II）配合物;1;4;7-三氮杂环壬烷;DNA结合;DNA裂解;

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1. A copper(II) complex of 1,4,7-triazacyclononane featuring acetate pendant: an efficient DNA cleavage agent [J] . JING QIAN, LI-PING WANG, JIN-LEI TIAN Journal of Coordination Chemistry . 2012,第1a2期

机译：1,4,7-三氮杂环壬烷铜（II）配合物，具有乙酸酯侧链：一种有效的DNA裂解剂
2. Synthesis, structure, and DNA cleavage properties of copper(II) complexes of 1,4,7-triazacyclononane ligands featuring pairs of guanidine pendants [J] . Tjioe L., Joshi T., Brugger J., Inorganic Chemistry: A Research Journal that Includes Bioinorganic, Catalytic, Organometallic, Solid-State, and Synthetic Chemistry and Reaction Dynamics . 2011,第2期

机译：1,4,7-三氮杂环壬烷配体与胍基悬垂对的铜（II）配合物的合成，结构和DNA裂解特性
3. Efficient plasmid DNA cleavage by copper(II) complexes of 1,4,7-triazacyclononane ligands featuring xylyl-linked guanidinium groups [J] . Tjioe L., Meininger A., Joshi T., Inorganic Chemistry: A Research Journal that Includes Bioinorganic, Catalytic, Organometallic, Solid-State, and Synthetic Chemistry and Reaction Dynamics . 2011,第10期

机译：具有二甲苯基连接的胍基的1,4,7-三氮杂环壬烷配体的铜（II）配合物有效切割质粒DNA
4. Synthesis of a tetranuclear vanadium cubane-type cluster protected by Co(III) complexes with 1,4,7-triazacyclononane ligands [C] . Keisuke Kawamoto, Sugiarto, Yoshihito Hayashi 日本化学会春季年会講演予稿集 . 2018

机译：由CO（III）配合物保护的四核钒嵌合型簇与1,4,7-三氮杂环烷配体保护
5. Physical and chemical investigations of iron complexes with 1,4,7-trimethyl-1,4,7-triazacyclononane and [2.2.2.2.3]adamanzane. [D] . Blakesley, David William. 2001

机译：与1,4,7-三甲基-1,4,7-三氮杂环壬烷和[2.2.2.2.3]金刚烷的铁配合物的物理和化学研究。
6. The Zn(II)-1,4,7-Trimethyl-1,4,7-Triazacyclononane Complex: A Monometallic Catalyst Active in Two Protonation States [O] . Marta Diez-Castellnou, Giovanni Salassa, Fabrizio Mancin, 1970

机译：Zn（II）-1,4,7-三甲基-1,4,7-三氮杂环壬烷络合物：在两个质子化状态下具有活性的单金属催化剂
7. (1,4,7-trimethyl-1,4,7-triazacyclononane)iron (III)-mediated cleavage of DNA: detection of selected protein-DNA interactions. [O] . Ehmann, A, Chafin, D, Lee, K M, 1998

机译：（1,4,7-三甲基-1,4,7-三氮杂环壬烷）铁（III）介导的DNA裂解：检测选定的蛋白质-DNA相互作用。
8. DNA Cleavage Using Artificial Hydrolases Based on Cobalt (III) Cyclen Complexes [R] . Chang, E. , Soni, R. , Goldman, E. R. , 2005

机译：基于钴（III）循环复合物的人工水解酶对DNa裂解的研究

A copper(II) complex of 1,4,7-triazacyclononane featuring acetate pendant: an efficient DNA cleavage agent

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