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首页> 外文期刊>Clinical chemistry and laboratory medicine: CCLM >Inter- and intra-individual variations of urinary endogenous metabolites in healthy male college students using (1)H NMR spectroscopy.
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Inter- and intra-individual variations of urinary endogenous metabolites in healthy male college students using (1)H NMR spectroscopy.

机译：使用（1）H NMR光谱分析健康男性大学生尿内源性代谢物的个体间和个体内变化。

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Abstract Background: Most human metabolomics studies have shown that spectral outputs of (1)H nuclear magnetic resonance fingerprinting are strongly influenced by inter- and intra-individual variations; however, few studies have been performed to evaluate the inter- and intra-individual variations in urinary endogenous metabolites. Methods: We recruited 30 male college students to evaluate the factors affecting intra- and inter-individual variations in urinary endogenous metabolites. Statistical analysis for variations in urinary metabolites was performed after eliminating outliers found in principal component analysis (PCA) plots. Results: Inter-individual variations were relatively low for 2-oxoglutarate, succinate, citrate, dimethylglycine, and taurine, but high for trimethylaminoxide (TMAO), hippurate, and lactate. Intra-individual variations for 2-oxoglutarate, citrate, dimethylglycine, and taurine were relatively low, but high for TMAO and hippurate. The factors affecting inter-individual variation of lactate were age, body mass index, beverages, and alcohol, whereas the factors affecting intra-individual variation of lactate were age and fish. Kim Chi intake affected the inter-individual variation of succinate, citrate, TMAO, and hippurate; however, it did not affect the intra-individual variation of endogenous metabolites. Conclusions: Our results showed that inter- and intra-individual variations in urinary endogenous metabolites were very large, and significant factors affecting inter- and intra-individual variation were diverse, even after eliminating outliers in PCA analysis. Clin Chem Lab Med 2009;47:188-94.
机译：摘要背景：大多数人类代谢组学研究表明，（1）H核磁共振指纹图谱的光谱输出受个体间和个体内变化的强烈影响;然而，很少有研究评估尿内源性代谢物的个体间和个体内变化。方法：我们招募了30名男大学生，以评估影响尿内源性代谢物个体内和个体间差异的因素。在排除主成分分析（PCA）图表中发现的异常值之后，进行尿中代谢物变化的统计分析。结果：2-氧戊二酸酯，琥珀酸酯，柠檬酸酯，二甲基甘氨酸和牛磺酸的个体间差异相对较低，而三甲基胺氧化物（TMAO），马尿酸酯和乳酸的个体差异较大。 2-氧戊二酸，柠檬酸，二甲基甘氨酸和牛磺酸的个体内变化相对较低，而TMAO和马尿酸的个体内变化较高。影响个体间乳酸变化的因素是年龄，体重指数，饮料和酒精，而影响个体内乳酸变化的因素是年龄和鱼类。 Kim Chi摄入量会影响琥珀酸，柠檬酸，TMAO和马尿酸的个体间差异;但是，它不影响内源性代谢物的个体内变化。结论：我们的结果表明，即使在PCA分析中消除了异常值之后，尿液内源性代谢物的个体间和个体内变化非常大，影响个体间和个体内变化的重要因素也多种多样。临床化学实验室杂志2009; 47：188-94。

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