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首页> 外文期刊>Journal of digestive diseases >Screening of atrophic gastritis and gastric cancer by serum pepsinogen, gastrin-17 and Helicobacter pylori immunoglobulin G antibodies.
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Screening of atrophic gastritis and gastric cancer by serum pepsinogen, gastrin-17 and Helicobacter pylori immunoglobulin G antibodies.

机译：通过血清胃蛋白酶原，胃泌素17和幽门螺杆菌免疫球蛋白G抗体筛查萎缩性胃炎和胃癌。

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OBJECTIVE: Currently the screening and diagnosis of gastric cancer and atrophic gastritis are mainly made by endoscopy and biopsy. The aim of this study was to evaluate the use of serum tests: serum pepsinogen I (PGI pepsinogen I/II ratio (PGR), gastrin-17 (G-17) and H. pylori-immunoglobulin G (IgG) antibodies to screen atrophic gastritis and gastric cancer. METHODS: A total of 458 patients were recruited, and each underwent endoscopy with biopsies before the serum tests were performed. These patients were divided into five groups based on the endoscopic and histological findings: 92 patients in the atrophic gastritis group, 58 in the gastric ulcer group, 90 in the duodenal ulcer group, 141 in the gastric cancer group (40 early gastric cancer and 101 advanced gastric cancer) and 77 (including mild non-atrophic gastritis) served as a control group. Serum samples for PGI and II, G-17, and H. pylori-IgG antibodies estimation were analyzed by ELISA. RESULTS: PGI and PGR values decreased significantly both in atrophic gastritis and gastric cancer groups (P<0.01). For the best discrimination of atrophic gastritis, the cut-off values of PGI and PGR were 82.3 microg/L and 6.05, respectively. The PGI, PGR and G-17 values were related significantly with the grades and/or sites of atrophic gastritis (P<0.01). Patients with atrophic corpus gastritis had low PGI and PGR values and high G-17 level, and patients with atrophic antral gastritis had low G-17 level. G-17 increased significantly in the gastric cancer group (P<0.01). PGI and PGR values were significantly lower in patients with advanced gastric cancer than in patients with early gastric cancer, while there was no difference in G-17 level between them. The positivity rate of H. pylori-IgG antibodies was 54.55% in the control group. The PGI level was higher in H. pylori positive patients than in H. pylori negative ones (P<0.001), while there was no difference in G-17 level between them. The positivity rates of H. pylori-IgG antibodies were over 85% in all other four groups. CONCLUSIONS: Low serum PGI, PGR and G-17 values are biomarkers of atrophic antral gastritis. Atrophic be screened by serum PGI and PGR values. Gastric cancer can be screened on the basis of increased serum G-17 and remarkedly low serum PGI and PGR values. The H. pylori infection is related to the change of PG level.
机译：目的：目前胃癌和萎缩性胃炎的筛查和诊断主要通过内窥镜检查和活检来进行。这项研究的目的是评估血清测试的使用：血清胃蛋白酶原I（PGI胃蛋白酶原I / II比（PGR），胃泌素17（G-17）和幽门螺杆菌免疫球蛋白G（IgG）抗体以筛查萎缩性方法：共招募458例患者，在行血清学检查之前均行内镜活检，根据内镜和组织学检查结果将其分为5组：萎缩性胃炎组92例对照组为胃溃疡组58例，十二指肠溃疡组90例，胃癌组141例（40例早期胃癌和101例晚期胃癌）和77例（包括轻度非萎缩性胃炎）。结果：萎缩性胃炎和胃癌组中，PGI和PGR值均显着下降（P <0.01），通过ELISA法分析了PGI和II，G-17和幽门螺杆菌IgG抗体的估计值（P <0.01）。胃炎PGI和PGR的截断值分别为82.3 microg / L和6.05。 PGI，PGR和G-17值与萎缩性胃炎的等级和/或部位显着相关（P <0.01）。萎缩性胃炎胃炎患者的PGI和PGR值低，G-17水平高;萎缩性胃窦炎患者G-17水平低。胃癌组中G-17明显升高（P <0.01）。晚期胃癌患者的PGI和PGR值显着低于早期胃癌患者，而两者之间的G-17水平无差异。对照组中幽门螺杆菌-IgG抗体的阳性率为54.55％。幽门螺杆菌阳性患者的PGI水平高于幽门螺杆菌阴性患者（P <0.001），而他们之间的G-17水平没有差异。在所有其他四组中，幽门螺杆菌-IgG抗体的阳性率均超过85％。结论：血清PGI，PGR和G-17值低是萎缩性胃窦炎的生物标志物。通过血清PGI和PGR值筛选萎缩。可以根据血清G-17升高和血清PGI和PGR值显着降低来筛查胃癌。幽门螺杆菌感染与PG水平的变化有关。

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