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首页> 外文期刊>Journal of drugs in dermatology: JDD >One-week treatment with 0.5% fluorouracil cream prior to cryosurgery in patients with actinic keratoses: a double-blind, vehicle-controlled, long-term study.
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One-week treatment with 0.5% fluorouracil cream prior to cryosurgery in patients with actinic keratoses: a double-blind, vehicle-controlled, long-term study.

机译：光化性角化病患者在冷冻手术前用0.5％氟尿嘧啶霜进行为期一周的治疗：一项双盲，媒介物对照的长期研究。

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摘要

Topical fluorouracil is currently approved for the treatment of actinic keratosis (AK) and is often used prior to or following cryosurgery as interval therapy in patients with severe AK lesions. No randomized, controlled studies are available to confirm anecdotal evidence suggesting pretreatment with fluorouracil is beneficial. This prospective, randomized, double-blind, vehicle-controlled study evaluated the effect of pretreatment with 0.5% fluorouracil cream (FC; Carac) or a vehicle cream (VC) once daily for 7 days to the face plus scalp, ears, neck, and/or lips in patients with > or = 5 visible or palpable AKs on the face prior to cryosurgery. Efficacy was determined by evaluating AK reduction and clearance (complete lack of AK lesions in the treatment area) at 4 weeks follow-up. Statistically significant decreases from baseline number of AKs were observed on all treatment areas in both groups. However, the mean number of facial AKs was significantly lower in the FC group at each treatment cycle (p = .011). No serious adverse events were considered related to treatment.
机译：目前，局部氟尿嘧啶已被批准用于治疗光化性角化病（AK），并经常在冷冻手术之前或之后作为间隔期疗法用于严重AK病变的患者。尚无随机对照研究证实传闻证据表明用氟尿嘧啶预处理是有益的。这项前瞻性，随机，双盲，赋形剂对照研究评估了每天用0.5％氟尿嘧啶霜（FC; Carac）或赋形剂霜（VC）对面部以及头皮，耳朵，脖子，进行冷冻手术前，脸上有≥5个可见或可触摸的AK的患者的嘴唇和/或嘴唇。通过评估4周随访时AK的减少和清除率（治疗区域完全没有AK病变）来确定疗效。在两组的所有治疗区域均观察到AKs基线数量的统计学显着下降。但是，在每个治疗周期的FC组中，面部AK的平均数量均显着降低（p = .011）。没有严重的不良事件被认为与治疗有关。

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