Trazodone generates m-CPP: in 2008 risks from m-CPP might outweigh benefits of trazodone.

Kast RE

首页> 外文期刊>The world journal of biological psychiatry: the official journal of the World Federation of Societies of Biological Psychiatry >Trazodone generates m-CPP: in 2008 risks from m-CPP might outweigh benefits of trazodone.

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Trazodone generates m-CPP: in 2008 risks from m-CPP might outweigh benefits of trazodone.

机译：曲唑酮产生m-CPP：2008年，m-CPP带来的风险可能超过曲唑酮的收益。

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Since deleterious effects of m-CPP, the primary catabolic metabolite of trazodone, were last reviewed 2 years ago, research data continue to accrue showing that clinically significant levels of m-CPP (a) are generated in patients using trazodone for sleep and (b) are present 24 h a day and (c) have potentially serious ill effects. This commentary argues that the documented potential for harm and multiple risks of m-CPP outweigh potential benefits of trazodone, given the development and marketing of many safer alternatives since trazodone's introduction in the 1980s.

机译：由于曲唑酮的主要分解代谢产物m-CPP的有害作用最近在2年前进行了综述，因此继续积累研究数据表明，使用曲唑酮进行睡眠的患者产生了临床上显着水平的m-CPP（a）。（b ）每天24公顷都存在，并且（c）有潜在的严重疾病。这篇评论认为，考虑到自1980年代曲唑酮问世以来许多更安全的替代品的开发和销售，所记录的m-CPP的危害和多重风险的潜在价值超过了曲唑酮的潜在益处。

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《The world journal of biological psychiatry: the official journal of the World Federation of Societies of Biological Psychiatry》 |2009年第4as2期|共4页
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Kast RE;
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正文语种 eng
中图分类神经病学与精神病学;
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1. Trazodone generates m-CPP: in 2008 risks from m-CPP might outweigh benefits of trazodone. [J] . Kast RE The world journal of biological psychiatry: the official journal of the World Federation of Societies of Biological Psychiatry . 2009,第4aS2期

机译：曲唑酮产生m-CPP：2008年，m-CPP带来的风险可能超过曲唑酮的收益。
2. HPLC analysis of the antidepressant trazodone and its main metabolite m-CPP in human plasma. [J] . Mercolini L, Colliva C, Amore M, Journal of Pharmaceutical and Biomedical Analysis: An International Journal on All Drug-Related Topics in Pharmaceutical, Biomedical and Clinical Analysis . 2008,第4a5期

机译：人体血浆中抗抑郁药物曲唑酮及其主要代谢物m-CPP的HPLC分析。
3. Attenuated response to m-CPP and to pentagastrin after repeated m-CPP in panic disorder (letter) [J] . Benjamin J, Geraci M, McCann U, Psychopharmacology . 1999,第2期

机译：恐慌症反复出现m-CPP后对m-CPP和五肽胃泌素的反应减弱（字母）
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5. The benefits of early comprehensive youth obesity prevention strategies outweigh the costs to consumers and reimbursers. [D] . Alver, Amalie. 2016

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6. Effect of chronic m-CPP on locomotion hypophagia plasma corticosterone and 5-HT2C receptor levels in the rat [O] . Kevin C F Fone, Rachel H Austin, Ian A Topham, 1998

机译：慢性m-CPP对大鼠运动吞咽血浆皮质酮和5-HT2C受体水平的影响
7. Decreased Neuroendocrine Responses to Meta-Chlorophenylpiperazine (m-CPP) but Normal Responses to Ipsapirone in Marathon Runners [O] . A Broocks 1999

机译：对Meta-氯苯基哌嗪（M-CPP）的神经内分泌反应减少，但在马拉松运动员中对IPSAPirone的正常反应

Trazodone generates m-CPP: in 2008 risks from m-CPP might outweigh benefits of trazodone.

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