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首页> 外文期刊>The world journal of biological psychiatry: the official journal of the World Federation of Societies of Biological Psychiatry >Biological markers for anxiety disorders, OCD and PTSD - a consensus statement. Part I: Neuroimaging and genetics
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Biological markers for anxiety disorders, OCD and PTSD - a consensus statement. Part I: Neuroimaging and genetics

机译：焦虑症，强迫症和创伤后应激障碍的生物学指标-共识声明。第一部分：神经影像学和遗传学

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Objectives: Biomarkers are defined as anatomical, biochemical or physiological traits that are specific to certain disorders or syndromes. The objective of this paper is to summarise the current knowledge of biomarkers for anxiety disorders, obsessive-compulsive disorder (OCD) and post-traumatic stress disorder (PTSD).Methods: Findings in biomarker research were reviewed by a task force of international experts in the field, consisting of members of the World Federation of Societies for Biological Psychiatry Task Force on Biological Markers and of the European College of Neuropsychopharmacology Anxiety Disorders Research Network.Results: The present article (Part I) summarises findings on potential biomarkers in neuroimaging studies, including structural brain morphology, functional magnetic resonance imaging and techniques for measuring metabolic changes, including positron emission tomography and others. Furthermore, this review reports on the clinical and molecular genetic findings of family, twin, linkage, association and genome-wide association studies. Part II of the review focuses on neurochemistry, neurophysiology and neurocognition.Conclusions: Although at present, none of the putative biomarkers is sufficient and specific as a diagnostic tool, an abundance of high-quality research has accumulated that will improve our understanding of the neurobiological causes of anxiety disorders, OCD and PTSD.
机译：目标：生物标志物被定义为特定于某些疾病或综合症的解剖，生化或生理特征。本文的目的是总结焦虑症，强迫症（OCD）和创伤后应激障碍（PTSD）的生物标志物的最新知识。该领域由世界生物精神病学协会生物标志物工作组成员和欧洲神经心理药理学焦虑症研究网络成员组成。包括大脑的结构形态，功能磁共振成像以及用于测量代谢变化的技术，包括正电子发射断层扫描等。此外，本综述报告了有关家庭，双胞胎，连锁，关联和全基因组关联研究的临床和分子遗传学发现。综述的第二部分着重于神经化学，神经生理学和神经认知。结论：尽管目前尚无任何推定的生物标志物作为诊断工具是足够的和特异性的，但已积累了大量高质量的研究，这些研究将增进我们对神经生物学的理解。焦虑症的原因，强迫症和创伤后应激障碍。

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