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首页> 外文期刊>The world journal of biological psychiatry: the official journal of the World Federation of Societies of Biological Psychiatry >Association between SCAP and SREBF1 gene polymorphisms and metabolic syndrome in schizophrenia patients treated with atypical antipsychotics
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Association between SCAP and SREBF1 gene polymorphisms and metabolic syndrome in schizophrenia patients treated with atypical antipsychotics

机译：非典型抗精神病药治疗的精神分裂症患者SCAP和SREBF1基因多态性与代谢综合征的相关性

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Objectives: The use of atypical antipsychotics (AAPs) in the treatment of schizophrenia has been relevant because of the high prevalence of metabolic syndrome (MetS). The sterol-regulatory element-binding protein (SREBP) pathway may contribute to the underlying pathophysiology of AAP-induced metabolic adverse effects. We explored the association between the variants of the sterol-regulatory element-binding transcription factor-1 (SREBF1) gene and the SREBP cleavage-activation protein (SCAP) gene with AAP-induced MetS in a genetic case-control study. Methods: Eleven single nucleotide polymorphisms (SNPs) of SREBF1 and five of SCAP were genotyped in a Han Chinese population in Beijing, China: a sample of 722 schizophrenia patients on monotherapy with AAPs (clozapine, olanzapine or risperidone). Metabolic parameters were collected and evaluated for MetS criteria. Results: The rs11654081 T-allele of the SREBF1 gene was significantly associated with an increased risk for MetS after correction (P=0.019, odds ratio, OR =2.56, 95% confidence interval, CI: 1.4 4-4.54). The rs11654081-TT genotype appeared more frequently in MetS than in non-MetS after correction (P=0.026, OR =2.37, 95% CI: 1.3 6-4.12). SCAP polymorphisms with drug-induced MetS were negative in this study. Conclusions: The genetic polymorphisms of SREBF1 could play a role in the mechanism for interindividual variation of AAP-induced MetS.
机译：目的：由于代谢综合征（MetS）的高患病率，非典型抗精神病药（AAPs）在精神分裂症的治疗中具有重要意义。固醇调节元件结合蛋白（SREBP）途径可能有助于AAP引起的代谢不良反应的潜在病理生理。在遗传病例对照研究中，我们探讨了固醇调节元件结合转录因子-1（SREBF1）基因和SREBP裂解激活蛋白（SCAP）基因的变体与AAP诱导的MetS之间的关联。方法：在中国北京的汉族人群中对SREBF1的11个单核苷酸多态性（SNP）和5个SCAP进行基因分型：对722例接受AAP（氯氮平，奥氮平或利培酮）单药治疗的精神分裂症患者的样本。收集代谢参数并评估MetS标准。结果：SREBF1基因的rs11654081 T等位基因与校正后的MetS风险增加显着相关（P = 0.019，优势比，OR = 2.56，95％置信区间，CI：1.4 4-4.54）。校正后，rs11654081-TT基因型在MetS中出现的频率高于非MetS（P = 0.026，OR = 2.37，95％CI：1.3 6-4.12）。在这项研究中，药物诱发的MetS的SCAP多态性为阴性。结论：SREBF1的遗传多态性可能在AAP诱导的MetS个体间变异的机制中起作用。

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