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首页> 外文期刊>The world journal of biological psychiatry: the official journal of the World Federation of Societies of Biological Psychiatry >Winter/summer seasonal changes in malondialdehyde formation as a source of variance in oxidative stress schizophrenia research.
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Winter/summer seasonal changes in malondialdehyde formation as a source of variance in oxidative stress schizophrenia research.

机译：丙二醛形成的冬季/夏季季节性变化是氧化应激精神分裂症研究中差异的来源。

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BACKGROUND: Malondialdehyde (MDA), an oxidative stress biological marker, is one of the most frequently used markers of lipid peroxidation in schizophrenia research. Data regarding MDA levels in schizophrenia are controversial. Our aim is to study the existence of winter/summer seasonal changes in serum MDA levels in schizophrenic patients. METHODS: Twenty-three clinically stable treated chronic paranoid schizophrenic outpatients were studied in summer and winter. Blood was sampled between 08:30 and 09:00 h. Serum MDA was determined by the thiobarbituric acid reactive substances technique. The clinical state was assessed by means of the Clinical Global Impression (CGI) scale. RESULTS: Mean serum MDA levels were significantly higher in summer than winter (2.49+/-0.25 vs. 1.86+/-0.11 nmol/ml, P<0.03). Summer MDA was increased by a 33.9% compared to winter MDA. Age, gender, smoking status, body mass index, psychopharmacological treatment, illness duration, age of illness onset and CGI did not affect significantly MDA levels. CONCLUSION: Our results show that serum MDA presents a winter/summer rhythm of formation, with higher levels in summer than winter. It is strongly advisable to take into account the summer/winter variation in MDA levels when researching into this field.
机译：背景：丙二醛（MDA）是一种氧化应激生物标志物，是精神分裂症研究中最常见的脂质过氧化标志物之一。关于精神分裂症中MDA水平的数据是有争议的。我们的目的是研究精神分裂症患者血清MDA水平的冬季/夏季季节性变化。方法：对23例临床稳定的慢性偏执型精神分裂症门诊患者进行了夏季和冬季的研究。在08:30至09:00之间取样血液。通过硫代巴比妥酸反应性物质技术测定血清MDA。通过临床总体印象量表（CGI）评估临床状态。结果：夏季的平均血清MDA水平明显高于冬季（2.49 +/- 0.25 vs. 1.86 +/- 0.11 nmol / ml，P <0.03）。夏季MDA比冬季MDA增加了33.9％。年龄，性别，吸烟状况，体重指数，心理药物治疗，疾病持续时间，疾病发作年龄和CGI对MDA水平没有明显影响。结论：我们的结果表明，血清MDA呈冬/夏节律形成，夏季水平高于冬季。在此领域进行研究时，强烈建议考虑MDA水平的夏季/冬季变化。

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