...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of drugs in dermatology: JDD >The role of topical vitamin D modulators in psoriasis therapy.
【24h】

The role of topical vitamin D modulators in psoriasis therapy.

机译：局部维生素D调节剂在牛皮癣治疗中的作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Psoriasis affects more than 5 million adults in the United States (U.S.), causing significant impairments in quality of life and incurring substantial costs in treatment. The disease is characterized by hyperproliferation and abnormal differentiation of epidermal keratinocytes resulting from a disordered immune response. Topical therapies, such as corticosteroids, are the most common treatment for psoriasis. However, long-term use of more potent topical corticosteroids is associated with potential risk for side effects. Topical vitamin D agents have been developed as a newer therapeutic option for use in place of, or in addition to, topical corticosteroids. These agents act to inhibit keratinocyte proliferation, normalize differentiation and modulate the activity of immune cells with minimal effect on serum calcium hemostasis. Calcipotriene is the most widely used member of this class, and is one of the most frequently prescribed topical agents for psoriasis. Although evidence suggests that it is approximately as effective as low-to-medium potency corticosteroids, it is associated with cutaneous irritation, especially when used in sensitive areas. Calcitriol ointment is a new option for topical therapy and is the only vitamin D3 ointment available for use in the U.S. and contains the naturally occurring active form of vitamin D3 that is associated with a relatively low rate of side effects.
机译：在美国（美国），牛皮癣影响超过500万成年人，造成生活质量的重大损害，并招致大量治疗费用。该疾病的特征是由于免疫反应紊乱导致表皮角质形成细胞过度增殖和异常分化。局部治疗，例如皮质类固醇，是牛皮癣最常见的治疗方法。但是，长期使用更有效的局部皮质类固醇激素可能会带来副作用。已经开发了局部维生素D剂作为替代局部皮质类固醇或除了局部皮质类固醇之外使用的较新的治疗选择。这些试剂可抑制角质形成细胞增殖，正常化分化并调节免疫细胞的活性，而对血钙止血的影响最小。钙泊三烯是这一类中使用最广泛的成员，并且是牛皮癣最常用的局部用药之一。尽管有证据表明它与中低效皮质类固醇激素差不多有效，但它与皮肤刺激有关，尤其是在敏感区域使用时。骨化三醇软膏是局部治疗的新选择，并且是美国唯一可用的维生素D3软膏，并且含有天然存在的维生素D3活性形式，且副作用相对较低。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号