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首页> 外文期刊>Journal of drugs in dermatology: JDD >An open-label, split-face study comparing the safety and efficacy of levulan kerastick (aminolevulonic acid) plus a 532 nm KTP laser to a 532 nm KTP laser alone for the treatment of moderate facial acne.
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An open-label, split-face study comparing the safety and efficacy of levulan kerastick (aminolevulonic acid) plus a 532 nm KTP laser to a 532 nm KTP laser alone for the treatment of moderate facial acne.

机译：一项开放标签的面部研究，比较了左旋酮拉美（氨基乙酰丙酸）加532 nm KTP激光与单独532 nm KTP激光治疗中度面部痤疮的安全性和有效性。

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摘要

Recent advances in light therapy coupled with photosensitizers offer alternatives to topical creams and gels and systemic oral agents for acne treatment. To examine the safety and efficacy of the photosensitizer 5-aminolevulinic acid (ALA) in patients with moderate-to-severe acne, a randomized, split-face study, using ALA on one side of the face, was followed by exposure of the entire face to 532 nm potassium titanyl phosphate (KTP) laser. Eight patients completed three treatments for up to 12 weeks. The average acne grading at baseline was 3.20, and improved to 2.12 at 12 weeks (34% improvement). Use of ALA improved acne by 52% compared with 32% on the side that did not receive the photosensitizer. Further studies are warranted to establish optimal parameters for photosensitizer use combined with light therapy for treatment of moderate-to-severe acne; however, the combined use of ALA and a 532 nm laser suggests promising results for acne treatment.
机译：结合光敏剂的光疗法的最新进展为痤疮治疗提供了局部乳膏，凝胶和全身性口服制剂的替代产品。为了检查光敏剂5-氨基乙酰丙酸（ALA）在中度至重度痤疮患者中的安全性和有效性，在面部一侧使用ALA进行了一项随机，分脸研究，随后对整个面部进行了暴露面对532 nm钛氧基磷酸钾（KTP）激光。八名患者完成了长达12周的三种治疗。基线时的平均粉刺等级为3.20，在12周时提高到2.12（提高了34％）。与未使用光敏剂的那一侧的32％相比，使用ALA可以将痤疮改善52％。有必要进行进一步的研究以建立光敏剂与光疗结合治疗中度至重度痤疮的最佳参数。但是，ALA和532 nm激光的组合使用表明治疗痤疮的结果令人鼓舞。

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