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首页> 外文期刊>Journal of drugs in dermatology: JDD >In vivo histological evaluation of non-insulated microneedle radiofrequency applicator with novel fractionated pulse mode
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In vivo histological evaluation of non-insulated microneedle radiofrequency applicator with novel fractionated pulse mode

机译：新型分脉冲模式的非绝缘微针射频涂药器的体内组织学评价

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INTRODUCTION: Microneedle radiofrequency is a novel method that allows non-thermal penetration of the epidermis followed by RF coagulation in selected depth of the dermis surrounded by zone of non-coagulative volumetric heating. The first generation of Microneedle RF applicators used insulated needles. These treatments were limited by a few factors, including low volume of dermal heating, lack of effect in the papillary dermis and pinpoint bleeding during the treatment. The system tested in this study (EndyMed PRO, Intensif applicator, EndyMed Medical, Cesarea, Israel) utilizes special extra sharp tapered noninsulated microneedles and a special pulse mode, allowing full coagulation during treatment and higher effective volume of dermal heat. METHODS: After Ethics Committee approval, one female pig (Type Large white X Landrace, 34 Kg) was chosen for the study. The animal was anesthetized using Ketamine, Xylazin and Isofluran. The EndyMed PRO, Intensif applicator (was used for treatment with different needle depth penetration (1mm-3.5 mm) and in multiple energy settings. Six mm punch biopsies were harvested for histological analysis at the following time points: immediately after the treatment, 4 days after the treatment and 14 days after the treatment. H&Eand Masson-Trichrome stains were processed. RESULTS: Visual inspection of the treated skin, immediately after the treatment, revealed arrays of pinpoint erythematous papules surrounded by undamaged epidermal tissue. Treatment field showed no sign of bleeding. Mild to moderate Erythema and Edema developed a few minutes after the treatment, varying according to the total energy delivered. The histologies taken 4-day after therapy showed in all energy settings, dry micro crusts over the treatment zones, with full healing of epidermis. In the 14-day specimens there was a replacement of the crusts/debris by a normal looking stratum corneum with complete healing of epidermis and dermis. DISCUSSION: The current in vivo study confirms that the EndyMed PRO Intensif applicator effective and predictable tool to create cylindrical micro zones of coagulation in the papillary and reticular dermis with minimal damage to the epidermis. The histologies taken 4 days and 14 days after treatment show rapid epidermal renewal with predictable volume of coagulation in dermis related to the length of the needle and the power used. Coagulation of capillaries during treatment allows a dry treatment field. The predictability of the effect and minimal downtime may offer a significant advantage over treatments with ablative fractional lasers of insulated RF microneedles.
机译：简介：微针射频是一种新颖的方法，它允许表皮进行非热渗透，然后在被非凝结体积加热区域包围的真皮选定深度中进行RF凝结。第一代Microneedle RF涂抹器使用绝缘针。这些治疗受到一些因素的限制，包括真皮加热量低，在乳头状真皮中缺乏作用以及治疗过程中的精确出血。在本研究中测试的系统（EndyMed PRO，Intensif涂抹器，EndyMed Medical，以色列Cesarea）利用特殊的超尖锥形非绝缘微针和特殊的脉冲模式，可以在治疗过程中充分凝结，并获得更高的真皮热量有效量。方法：经伦理委员会批准，选择一头雌猪（大白X长白猪，34公斤）进行研究。用氯胺酮，Xylazin和异氟醚麻醉动物。 EndyMed PRO Intensif涂药器（用于不同深度的针刺深度（1mm-3.5 mm）和多种能量设置的治疗。在以下时间点采集6 mm的打孔活组织检查以进行组织学分析：治疗后第4天结果：在治疗后和治疗后14天，对H＆E和Masson-Trichrome染色进行了处理结果：目视检查治疗后的皮肤，治疗后即刻发现了一系列针尖状的红斑丘疹，周围未受损的表皮组织，治疗区域未见任何迹象。治疗后几分钟，轻度至中度的红斑和水肿发生，具体取决于所释放的总能量，在治疗后4天进行的组织学检查显示，在所有能量设置下，治疗区域上的干燥微结rust均能完全治愈。在14天的标本中，外观正常的角质层已完全治愈了硬皮/碎片表皮和真皮。讨论：当前的体内研究证实EndyMed PRO Intensif敷贴器是有效且可预测的工具，可在乳头状和网状真皮中形成圆柱形的微凝集微区，而对表皮的损害最小。治疗后4天和14天采取的组织学检查显示表皮快速更新，真皮中可预测的凝固量与针的长度和使用的力量有关。在治疗期间毛细管的凝结允许干燥的治疗领域。效果的可预测性和最少的停机时间可能比绝缘射频微针烧蚀性分级激光治疗具有明显优势。

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