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首页> 外文期刊>Journal of drugs in dermatology: JDD >A Method for Maintaining the Clinical Results of 4% Hydroquinone and 0.025% Tretinoin With a Cosmeceutical Formulation
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A Method for Maintaining the Clinical Results of 4% Hydroquinone and 0.025% Tretinoin With a Cosmeceutical Formulation

机译：药妆配方保持4％对苯二酚和0.025％维甲酸的临床效果的方法

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摘要

Facial dyspigmentation treatment is an unmet need in dermatology with increasing challenges due to the questionable safety of hydroquinone. This research examined a new OTC formulation containing hydroxyphenoxy propionic acid, ellagic acid, yeast extract, and salicylic acid on subjects who previously completed 12 weeks of treatment with 4% hydroquinone and 0.025% retinoic acid. The goal of this study was to evaluate the skin lightening and tolerability profile of a 20-week maintanence therapy with a cosmeceutical formulation during the summer months. 33 healthy subjects ages 25-60 years with moderate facial dyspigmentation defined as a score of 3 on a 5-point scale were enrolled. There was statistically significant improvement at week 20 in terms of even skin tone (P<0.001), spot intensity (P<0.001), spot size (P<0.05) and overall hyperpigmentation (P=0.002).
机译：由于对苯二酚的安全性存疑，面部皮肤色素沉着的治疗是皮肤病学中未满足的需求，并且挑战日益增加。这项研究对以前用4％对苯二酚和0.025％视黄酸治疗12周的受试者使用了一种新的OTC制剂，该制剂含有羟基苯氧基丙酸，鞣花酸，酵母提取物和水杨酸。这项研究的目的是评估在夏季月份采用药妆配方进行20周维持治疗的皮肤增白和耐受性。招募了33名年龄在25至60岁之间的中度色素沉着症的健康受试者，其在5分制中的得分为3。在第20周，就均匀肤色（P <0.001），斑点强度（P <0.001），斑点大小（P <0.05）和总体色素沉着过度（P = 0.002）而言，统计学上有显着改善。

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