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首页> 外文期刊>Journal of drugs in dermatology: JDD >Efficacy and Safety of Minoxidil 5% Foam in Combination With a Botanical Hair Solution in Men With Androgenic Alopecia
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Efficacy and Safety of Minoxidil 5% Foam in Combination With a Botanical Hair Solution in Men With Androgenic Alopecia

机译：米诺地尔5％泡沫与植物性头发溶液联合治疗雄激素性脱发的疗效和安全性

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Androgenic alopecia (AGA) is the most common type of hair loss in men, characterized by hair miniaturization, hairline recession, and vertex balding. It affects approximately 50% of men, negatively affecting self-esteem and sociability. Topical minoxidil formulations are approved up to a 5% concentration for men, but patient adherence to treatment is challenged by gradual results that may be perceived as a lack of initial benefit. Herbal extracts, which are also believed to promote healthier-looking hair, have a long history of use in hair care formulations. The safety and efficacy of a twice-daily regimen of 5% minoxidil foam used in combination with a novel botanical hair solution was evaluated in a 12-week, multicenter, single-arm, open label study in 56 subjects with mild to moderate AGA. Assessments included investigator ratings of improvement and subject self-ratings of satisfaction. Investigator ratings indicated significant improvement in scalp hair coverage and perception of overall treatment benefit in as early as 4 weeks (P<.001). Subject self-ratings were significant for improved hair growth and hair appearance in as few as 4 weeks (P<.05). The regimen was well tolerated, and subjects indicated a high degree of satisfaction. Investigator and subject-assessed efficacy and subject satisfaction with this novel regimen provide clinicians with an effective treatment option for AGA that also provides a high level of patient satisfaction, which may help promote patient adherence to long-term treatment.
机译：雄激素性脱发（AGA）是男性最常见的脱发类型，其特征是头发微型化，发际线衰退和顶点脱发。它影响约50％的男性，对自尊和社交能力产生负面影响。局部用米诺地尔制剂经批准可用于男性，浓度最高可达到5％，但患者对治疗的依从性受到逐步结果的挑战，该结果可能被认为缺乏最初的获益。草药提取物也被认为可以促进头发看起来更健康，在头发护理配方中的使用历史悠久。一项为期12周，多中心，单臂，开放标签的研究在56位轻度至中度AGA患者中进行了为期12周的多中心单臂开放标签研究，评估了每日两次5％米诺地尔泡沫与新型植物毛发溶液联合使用的安全性和有效性。评估包括研究者的改善等级和受试者的自我满意度。研究者的评级表明，早在4周内，头皮头发覆盖率和总体治疗效果的感知就有了显着改善（P <.001）。受试者的自我评价对于在短短4周内改善头发生长和头发外观具有显着意义（P <.05）。该方案耐受性良好，受试者表示高度满意。研究人员和受试者评估的疗效以及受试者对这种新方案的满意度为临床医生提供了AGA的有效治疗选择，也为患者带来了很高的满意度，这可能有助于促进患者坚持长期治疗。

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