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首页> 外文期刊>Journal of cutaneous medicine and surgery >Off-label uses of topical vitamin D in dermatology: A systematic review
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Off-label uses of topical vitamin D in dermatology: A systematic review

机译：皮肤病学中局部使用维生素D的标签外使用：系统评价

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Background: Topical vitamin D is approved by the US Food and Drug Administration for the treatment of psoriasis but is also used off-label in the treatment of a variety of cutaneous diseases despite a lack of evidence-based guidelines. Objective: The objective of this study was to provide evidence-based clinical guidelines for the off-label use of topical vitamin D in the treatment of dermatologic disease. Methods: A systematic literature review was conducted via the MEDLINE, Embase, and CENTRAL databases for off-label uses of topical vitamin D analogues in the treatment of dermatologic disease other than psoriasis. The data were synthesized, and evidence-based recommendations were rendered according to the highest level of evidence available. Results: A total of 165 articles met the inclusion criteria. A moderate to strong recommendation was given for the use of topical vitamin D in combination with corticosteroids and phototherapy in vitiligo and as monotherapy for various ichthyoses, morphea, pityriasis alba, prurigo nodularis, and polymorphous light eruption. There is evidence showing that topical vitamin D is ineffective in the treatment of actinic keratosis, seborrheic keratosis, lichen planus, seborrheic dermatitis, alopecia areata, chemotherapy-induced alopecia, and hypertrophic scars. Conclusion: Topical vitamin D analogues have an important role in the off-label treatment of dermatologic disease, but higher quality studies are still required.
机译：背景：局部维生素D已获得美国食品和药物管理局（US Food and Drug Administration）的批准用于治疗牛皮癣，但尽管缺乏循证指南，但仍被标签用于治疗多种皮肤疾病。目的：本研究的目的是提供针对循证医学的临床指导方针，以用于非处方使用局部维生素D治疗皮肤病。方法：通过MEDLINE，Embase和CENTRAL数据库进行系统的文献综述，探讨局部使用维生素D类似物在银屑病以外的皮肤病治疗中的非标签使用。对数据进行了综合，并根据可获得的最高证据水平提出了基于证据的建议。结果：共有165篇文章符合纳入标准。对于将局部维生素D与皮质类固醇结合使用以及在白癜风中进行光疗，以及将其用作各种鱼鳞，吗啡，白癜风，结节性瘙痒和多形性轻症发作的单一疗法，提出了中等至强烈的建议。有证据表明，局部使用维生素D在治疗光化性角化病，脂溢性角化病，扁平苔藓，脂溢性皮炎，斑秃，化学疗法引起的斑秃和肥厚性疤痕方面无效。结论：局部维生素D类似物在皮肤病的标签外治疗中具有重要作用，但仍需要更高质量的研究。

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