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首页> 外文期刊>Journal of cutaneous pathology >CD34 expression in primary cutaneous malignant melanoma: apropos of a case and review of the aberrant melanoma phenotype.
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CD34 expression in primary cutaneous malignant melanoma: apropos of a case and review of the aberrant melanoma phenotype.

机译：CD34在原发性皮肤恶性黑色素瘤中的表达：约1例，并回顾异常黑色素瘤的表型。

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BACKGROUND: The histological diagnosis of malignant melanoma can be challenging. Immunohistochemical techniques may define a critical role in certain cases, specifically in establishing a primary diagnosis of melanoma. CD34 is a hemopoietic stem cell antigen expressed in bone marrow and endothelial cells, and may also be expressed in vascular and spindle cell tumors; it is generally negative in malignant melanoma. CASE REPORT: An 83-year-old white female presented with a 3-4 mm area on her right upper back, which had been present for several years. Histologic sections showed a polypoid distortion by sheets and nodules of transformed amelanotic melanocytes lying in intimate apposition to an attenuated epidermis without a concomitant radial growth phase. Tumor cells were extensively S-100 and CD34 positive and showed focal immunoreactivity with melan-A and HMB-45. DISCUSSIONS: We present a case of malignant melanoma of nodular subtype, which strongly expressed CD34. The spectrum of abnormal phenotypes inmalignant melanoma is reviewed, and a possible explanation for the presence of CD34 is discussed. This case demonstrates the potential of malignant melanoma to express CD34, defining an infrequently recognized aberrant phenotype. Whether or not expression of this marker is associated with a more aggressive clinical course remains to be determined.
机译：背景：恶性黑色素瘤的组织学诊断可能具有挑战性。免疫组织化学技术可能在某些情况下（特别是在建立黑色素瘤的初步诊断中）起关键作用。 CD34是在骨髓和内皮细胞中表达的造血干细胞抗原，也可能在血管和梭形细胞肿瘤中表达;在恶性黑色素瘤中通常为阴性。病例报告：一位83岁的白人女性在她的右上背部出现了3-4毫米的区域，该区域已经存在了几年。组织学切片显示，被转化的黑素细胞黑素细胞的薄片和结节形成息肉状变形，它们与衰减的表皮紧密并列，而没有伴随的放射状生长期。肿瘤细胞广泛为S-100和CD34阳性，并显示与melan-A和HMB-45的局部免疫反应性。讨论：我们介绍了一个结节性亚型恶性黑色素瘤病例，该病例强烈表达CD34。审查了恶性黑色素瘤的异常表型的光谱，并讨论了CD34存在的可能解释。该病例证明了恶性黑色素瘤表达CD34的潜力，从而定义了一种罕见的异常表型。该标志物的表达是否与更具侵略性的临床病程相关，尚待确定。

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