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首页> 外文期刊>Journal of cutaneous pathology >Cutaneous granular cell tumor with epidermal involvement: a potential mimic of melanocytic neoplasia.
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Cutaneous granular cell tumor with epidermal involvement: a potential mimic of melanocytic neoplasia.

机译：表皮受累的皮肤颗粒细胞瘤：黑色素细胞瘤的潜在模仿。

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BACKGROUND: Cutaneous granular cell tumor (GCT) may present with extension into the junctional region of the epidermis and thus may mimic melanocytic neoplasms. METHODS: We reviewed three cases of cutaneous GCT where a melanocytic neoplasm was either initially diagnosed or considered in the differential diagnosis. Histopathology was evaluated in regards to features associated with melanocytic neoplasms. Immunohistochemistry was performed to delineate a panel useful in the distinction of these and other entities. RESULTS: All cases consisted of spindle and epithelioid cells with granular cytoplasm and bland nuclei and were centered in the superficial dermis with extension into the epidermis. Two cases resembled Spitz nevi and one case demonstrated lentiginous growth. All cases stained positively with calretinin and inhibin. Two of the three cases stained diffusely with S100 and 2/2 cases with CD56. HAM56 and CD68 were positive in one case and another showed positivity for NSE and PGP9.5. HMB-45, tyrosinase, and Melan-A were non-reactive in all cases tested. CONCLUSIONS: GCT may involve the epidermis and has a growth pattern similar to melanocytic neoplasms. An immunohistochemical (IHC) panel including S100, Melan-A, tyrosinase, HMB-45, CD56, CD68, calretinin, inhibin, and PGP9.5 may aid in the distinction and may spare the patient from unnecessary morbidity.
机译：背景：皮肤颗粒细胞瘤（GCT）可能延伸到表皮的交界区域，因此可能模仿黑素细胞瘤。方法：我们回顾了三例皮肤GCT病例，这些病例最初被诊断为黑色素细胞性肿瘤，或在鉴别诊断中被考虑。就与黑素细胞性肿瘤相关的特征进行了组织病理学评估。进行了免疫组化分析以描绘出可用于区分这些实体和其他实体的面板。结果：所有病例均由纺锤体和上皮样细胞组成，具有颗粒状细胞质和平淡的细胞核，并集中在浅表真皮，延伸到表皮。 2例类似于斯皮茨痣，1例表现为缓慢生长。所有病例均被钙网蛋白和抑制素染色阳性。 3例中有2例用S100弥漫性染色，2/2例用CD56弥漫性染色。 HAM56和CD68在一例中为阳性，另一例对NSE和PGP9.5呈阳性。在所有测试的案例中，HMB-45，酪氨酸酶和Melan-A均无反应。结论：GCT可能累及表皮，其生长方式与黑素细胞性肿瘤相似。包括S100，Melan-A，酪氨酸酶，HMB-45，CD56，CD68，钙网蛋白，抑制素和PGP9.5的免疫组化（IHC）面板可能有助于区分，并且可以使患者免于不必要的发病。

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