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首页> 外文期刊>Journal of cutaneous pathology >Dermatofibrosarcoma protuberans and giant cell fibroblastoma exhibit CD99 positivity.
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Dermatofibrosarcoma protuberans and giant cell fibroblastoma exhibit CD99 positivity.

机译：隆突性皮肤皮肤肉瘤和巨细胞成纤维细胞瘤表现出CD99阳性。

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According to most authors, dermatofibrosarcoma protuberans (DFSP) and giant cell fibroblastoma (GCF) represent the adult and juvenile forms, respectively, of the same disease entity, as evidenced by similar morphology, an identical chromosomal translocation, and CD34 positivity. It has been shown that DFSP and nuchal-type fibroma (NTF) (which is also CD34-positive) are related lesions, and that there might possibly be a continuum between the two. In addition, NTF exhibits CD99 positivity. It was therefore, hypothesized that both DFSP and GCF would show similar immunopositivity for CD99. Archives of pathology at several institutions were searched for DFSP and GCF tissue blocks. A total of 29 DFSP and 5 GCF were analyzed by immunohistochemistry for expression of CD99. Twenty-three of 29 DFSP (79%) and 2 of 5 GCP (40%) expressed CD99. Comparison of CD99 and CD34 showed that the non-tumoral periphery of DFSP was less probable to be CD99 positive, but this finding was not statistically significant.
机译：根据大多数作者的说法，隆突性皮肤皮肤肉瘤（DFSP）和巨细胞成纤维细胞瘤（GCF）分别代表同一疾病实体的成年和少年形式，这由相似的形态，相同的染色体易位和CD34阳性所证明。已经表明，DFSP和颈髓型纤维瘤（NTF）（也是CD34阳性）是相关的病变，并且两者之间可能存在连续体。此外，NTF表现出CD99阳性。因此，假设DFSP和GCF对CD99都显示相似的免疫阳性。搜索了几个机构的病理学档案中的DFSP和GCF组织块。通过免疫组织化学分析了总共29个DFSP和5个GCF的CD99表达。 29个DFSP中的23个（79％）和5个GCP中的2个（40％）表达CD99。 CD99和CD34的比较显示DFSP的非肿瘤周边不太可能是CD99阳性的，但这一发现在统计学上并不显着。

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