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首页> 外文期刊>Journal of cutaneous pathology >Her-2eu evaluation in Sister Mary Joseph's nodule from breast carcinoma: a case report and review of the literature.
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Her-2eu evaluation in Sister Mary Joseph's nodule from breast carcinoma: a case report and review of the literature.

机译：Her-2 / neu在乳腺癌患者玛丽约瑟夫结节中的评估：病例报告和文献复习。

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摘要

Sister Mary Joseph's nodule (SMJN) involving the umbilicus can often be a clinical sign of metastatic cancer, but rarely cancer originating from the breast. We report a rare case of umbilical metastases from breast cancer and reviewed the literature. A 54-year-old woman was referred to a pre-surgery clinic for an examination of an umbilical nodule. The patient had a history of ductal breast carcinoma. Cytological smear from fine needle aspiration showed epithelial neoplastic cells resembling those of breast carcinoma. Neoplastic cells from tissue were positive for cytokeratin 8-18, estrogen and progesterone receptor and negative for E-cadherin and had a low proliferative index. Her-2eu immunodetection showed a 2+ equivocal positive rate, but Her-2eu gene amplification was found on the cytological smear by fluorescence in situ hybridization analysis. Similar results were obtained within a tissue section. Concordant findings have been obtained when comparing the recent American Society of Clinical Oncology/College of American Pathologists scoring system. Fine needle aspiration from the SMJN is a useful tool for the diagnosis of metastatic breast cancer. Furthermore, the predictive biomarkers for tumors of the breast, hormonal receptors and Her-2eu not only assist with the identification of the source of the metastatic disease but also provide clinical information for patient management.
机译：涉及脐部的玛丽·约瑟夫姐妹结节（SMJN）通常可能是转移性癌症的临床体征，但很少是源于乳腺癌的癌症。我们报告了罕见的乳腺癌脐带转移病例，并复习了文献。一名54岁的妇女被转介到术前诊所检查脐结节。该患者有导管癌的病史。细针穿刺的细胞学涂片显示上皮肿瘤细胞与乳腺癌相似。组织中的肿瘤细胞的细胞角蛋白8-18，雌激素和孕激素受体阳性，而E-钙粘蛋白阴性，增殖指数低。 Her-2 / neu免疫检测显示2+的阳性率，但是通过荧光原位杂交分析在细胞学涂片上发现了Her-2 / neu基因扩增。在组织切片内获得了相似的结果。比较最近的美国临床肿瘤学会/美国病理学家学院的评分系统时，已经获得了一致的发现。 SMJN的细针穿刺术是诊断转移性乳腺癌的有用工具。此外，乳腺肿瘤，荷尔蒙受体和Her-2 / neu的预测生物标志物不仅有助于鉴定转移性疾病的来源，而且还为患者管理提供了临床信息。

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