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首页> 外文期刊>Journal of cutaneous pathology >Myoepithelioma with melanocytic colonization (melanocytic myoepithelioma): a case report.
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Myoepithelioma with melanocytic colonization (melanocytic myoepithelioma): a case report.

机译：伴有黑素细胞定植的肌上皮瘤（黑素细胞肌上皮瘤）：1例。

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摘要

Mixed tumors of the salivary glands and the skin (also known as chondroid syringomas) contain epithelial and myoepithelial components in a chondroid to myxoid stroma. Lesions that are composed solely of cells with myoepithelial differentiation are known as myoepitheliomas. These tumors have been well described in the salivary glands and many other sites, and within the past decade, cutaneous myoepitheliomas have been described as well. Immunohistochemically, these lesions are typically positive for S-100, cytokeratin and/or epithelial membrane antigen (EMA), with variable positivity for glial fibrillary acid protein and myogenic markers such as actin and calponin. Rare case reports have described the presence of melanocytes in mixed tumors of the salivary glands, but they have not been shown in mixed tumors or myoepitheliomas of the skin. We report a case of a cutaneous myoepithelioma with a distinct subpopulation of spindled to dendritic melanocytes, confirmed by immunohistochemical positivity for S-100, HMB-45 and melanoma antigen recognized by T-cells-1 (Mart-1).
机译：唾液腺和皮肤混合瘤（也称为软骨样滑液瘤）在软骨样粘液样基质中含有上皮和肌上皮成分。仅由具有肌上皮分化的细胞组成的病变称为肌上皮瘤。这些肿瘤已经在唾液腺和许多其他部位得到了很好的描述，并且在过去的十年中，也已经描述了皮肤肌上皮瘤。免疫组织化学分析，这些病变通常对S-100，细胞角蛋白和/或上皮膜抗原（EMA）呈阳性，而对胶质纤维酸蛋白和肌原性标志物（如肌动蛋白和钙蛋白）的阳性率则不同。罕见的病例报告描述了唾液腺混合瘤中存在黑素细胞，但皮肤混合瘤或肌上皮瘤中未见黑素细胞。我们报告了一例皮肤肌上皮瘤，其中纺锤状树突状黑色素细胞具有明显的亚群，通过对S-100，HMB-45和T-cells-1（Mart-1）识别的黑色素瘤抗原的免疫组织化学阳性证实。

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