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首页> 外文期刊>Journal of drug delivery science and technology >From nanoemulsions to nanostructured lipid carriers: A relevant development in dermal delivery of drugs and cosmetics
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From nanoemulsions to nanostructured lipid carriers: A relevant development in dermal delivery of drugs and cosmetics

机译：从纳米乳剂到纳米结构脂质载体：药物和化妆品通过皮肤输送的相关进展

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摘要

Recent advances in nanotechnology have led to the development of nano-scale drugs and delivery systems to improve drug therapeutic effectiveness. Between the end of '50 and the beginning of '60, the first colloidal systems in the nano-metric range were achieved by chance. Several research highlighted the usefulness of these nano-carriers as drug delivery systems to overcome biological barriers later on. Since few drugs are effective after their topical application, due to the barrier function of the skin, colloidal systems have being widely explored as carriers to improve drug skin permeation. In particular, a great deal of attention has been paid to delivery systems based on highly biocompatible and biodegradable components such as lipids and phospholipids. As a result, different types of nano-carriers such as liposomes, microemulsions, solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) have been developed. This review will focus on the nano-carriers arising from the first colloidal systems consisting of water, lipids and surfactants, i.e. microemulsions and their consequent improvement through the development of SLN and NLC. The properties of these nano-carriers will be discussed along with their applications as skin delivery systems both in pharmaceutical and cosmetic fields. (C) 2015 Elsevier B.V. All rights reserved.
机译：纳米技术的最新进展导致了纳米级药物和递送系统的开发，以提高药物治疗效果。在50年代末和60年代初之间，偶然获得了纳米范围内的第一个胶体体系。几项研究强调了这些纳米载体作为药物输送系统的作用，以克服以后的生物学障碍。由于在局部应用后几乎没有药物有效，由于皮肤的屏障功能，胶体系统已被广泛地用作改善药物皮肤渗透的载体。尤其是，基于高度生物相容性和可生物降解成分（例如脂质和磷脂）的递送系统已引起了极大的关注。结果，已经开发了不同类型的纳米载体，例如脂质体，微乳剂，固体脂质纳米颗粒（SLN）和纳米结构脂质载体（NLC）。这篇综述将集中在由水，脂质和表面活性剂即微乳组成的第一种胶体体系中产生的纳米载体及其通过SLN和NLC的发展而得到的改进。将讨论这些纳米载体的性质及其在制药和化妆品领域中作为皮肤输送系统的应用。 （C）2015 Elsevier B.V.保留所有权利。

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