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首页> 外文期刊>Journal of drug delivery science and technology >Transungual drug delivery: An update
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Transungual drug delivery: An update

机译：跨部药物递送：最新动态

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Topical therapy continues to be the treatment of choice for the patients and clinicians in treating certain infections of the nails. Topical treatment is widely accepted as an adjunct with oral therapy to improve the cure rates, reduce the treatment duration, cut down the treatment cost and enhance the therapeutic outcomes. However, effectiveness of topical therapy continues to pose a challenge owing to the poor permeability of the nail plate to many therapeutic agents and the prolonged treatment periods. Research over the past one decade has been focused to improve the transungual permeation using chemical penetration enhancers, mechanical methods and physical methods. Disrupting the dorsal surface of the nail by treating with penetration enhancers or etching agents or abrasion or filing of the nail plate has proved to drastically improve the efficacy of topical therapy. The present review is an effort to update the different chemical enhancers and etching agents used to enhance the transungual permeability.
机译：在治疗指甲的某些感染中，局部治疗仍然是患者和临床医生的首选治疗方法。局部治疗作为口服治疗的辅助手段已被广泛接受，以提高治愈率，缩短治疗时间，降低治疗成本并提高治疗效果。然而，由于指甲板对许多治疗剂的不良渗透性和延长的治疗时间，局部治疗的有效性继续构成挑战。在过去的十年中，研究一直集中于使用化学渗透促进剂，机械方法和物理方法来改善穿刺通透性。通过用渗透促进剂或蚀刻剂处理或磨蚀或锉指甲板来破坏指甲的背表面已被证明可以大大改善局部治疗的功效。本综述是努力更新用于增强穿刺通透性的不同化学增强剂和蚀刻剂。

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