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首页> 外文期刊>Journal of cutaneous pathology >Clear cell acanthoma with changes of eccrine syringofibroadenoma: Reactive change or clue to etiology?
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Clear cell acanthoma with changes of eccrine syringofibroadenoma: Reactive change or clue to etiology?

机译：透明细胞棘皮瘤伴内分泌性腺样纤维化腺瘤改变：反应性改变还是病因学线索？

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摘要

We observed two patients with solitary lesions showing features of clear cell acanthoma with underlying eccrine syringofibroadenoma-like changes. The pathogenesis of these entities has been debated since their original descriptions, with most recent literature suggesting that both may represent reactive phenomena rather than true neoplasms. Our observation prompted us to perform a retrospective review of clear cell acanthoma cases to determine the frequency of such associated eccrine syringofibroadenoma changes. Of 47 examined cases of clear cell acanthoma, 9 (19%) showed associated changes of eccrine syringofibroadenoma. Immunohistochemical evaluation performed on a subset of cases identified similar but slightly divergent differentiation patterns within the lesions. While epithelial membrane antigen and PAS expression were similar in both components (although slightly different in intensity), the regions resembling eccrine syringofibroadenoma displayed additional immunoreactivities, supporting the presence of two distinct components. We have found that the concurrence of clear cell acanthoma with syringofibroadenomatous changes is more frequent than generally appreciated and suggest that these entities may share derivation from the eccrine apparatus.
机译：我们观察到两名孤立病灶患者，其表现为透明细胞棘皮瘤的特征，并伴有潜在的内分泌腺样腺样肾上腺皮质瘤样变化。自从最初的描述以来，这些实体的发病机理一直在争论中，最新的文献表明这两个实体都可能代表反应性现象，而不是真正的肿瘤。我们的观察促使我们对透明细胞棘皮瘤病例进行回顾性研究，以确定此类相关的内分泌腺体腺瘤性腺瘤改变的频率。在检查的47例透明细胞棘皮瘤病例中，有9例（19％）显示出内分泌性syringofibroadenoma的相关变化。对部分病例进行的免疫组织化学评估确定了病变内相似但略有不同的分化模式。尽管两种成分的上皮膜抗原和PAS表达相似（尽管强度略有不同），但类似于内分泌性腺样肾上腺癌的区域显示了额外的免疫反应性，支持了两种不同成分的存在。我们已经发现，透明细胞棘皮瘤与腺瘤性突触并发的并发性要比普遍认可的更为频繁，并且表明这些实体可能共享来自内分泌器官的衍生物。

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