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首页> 外文期刊>Journal of cutaneous pathology >Multinucleate cell angiohistiocytoma with hypertrophic nerves
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Multinucleate cell angiohistiocytoma with hypertrophic nerves

机译：肥厚神经的多核细胞血管组织细胞瘤

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摘要

Multinucleate cell angiohistiocytoma (MCAH) represents a rare benign skin lesion characterized by multiple papules that are usually found on the distal extremities or face of middle-aged women. We report on a 60-year-old male with a history of monoclonal gammopathy and severe rheumatoid arthritis who had several asymptomatic red-to-livid papules grouped on the right side of his trunk. The lesions had been present for a few years and were gradually enlarging. Biopsies from three lesions showed a spectrum of changes consisting of a proliferation of small venules together with thickened collagen bundles and increased numbers of interstitial cells including bizarre, multinucleated giant cells. Immunohistochemically, the multinucleated cells were positive for vimentin and lysozyme while the interstitial cells expressed CD68, factor XIIIa and lysozyme. Interestingly, strikingly enlarged dermal nerves were seen in all the three biopsies and two of the biopsies showed an accompanying infiltrate of lymphocytes and plasma cells.
机译：多核细胞血管组织细胞瘤（MCAH）代表一种罕见的良性皮肤病变，其特征是多发丘疹，通常在中年妇女的远端或面部可见。我们报告了一位60岁的男性，患有单克隆性丙种球蛋白病和严重的类风湿性关节炎病史，他的躯干右侧有几个无症状的红色至淡黄色丘疹。病变已经存在了几年，并且逐渐扩大。来自三个病变的活检显示一系列变化，包括小静脉的增生，胶原束的增厚以及包括奇异的多核巨细胞在内的间质细胞数量的增加。免疫组织化学观察，多核细胞波形蛋白和溶菌酶呈阳性，而间质细胞表达CD68，XIIIa因子和溶菌酶。有趣的是，在所有三个活检组织中都观察到明显的真皮神经增大，其中两个活检组织伴随着淋巴细胞和浆细胞的浸润。

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